2021.10.15

Structure-based classification of tauopathies

(Nature. 2021 Oct;598(7880):359-363. doi: 10.1038/s41586-021-03911-7. Epub 2021 Sep 29.)

Shi Y1, Zhang W1, Yang Y1, Murzin AG1, Falcon B1, Kotecha A2, van Beers M2, Tarutani A3, Kametani F3, Garringer HJ4, Vidal R4, Hallinan GI4, Lashley T5, Saito Y6, Murayama S7, Yoshida M8, Tanaka H9, Kakita A9, Ikeuchi T10, Robinson AC11, Mann DMA11, Kovacs GG12,13, Revesz T5, Ghetti B4, Hasegawa M3, Goedert M14, Scheres SHW15.

1MRC Laboratory of Molecular Biology, Cambridge, UK.
2Thermo Fisher Scientific, Eindhoven, The Netherlands.
3Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
4Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
5Department of Neurodegenerative Disease and Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
6Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
7Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, University of Osaka, Osaka, Japan.
8Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.
9Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
10Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
11Clinical Sciences Building, University of Manchester, Salford Royal Foundation Trust, Salford, UK.
12Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
13Institute of Neurology, Medical University of Vienna, Vienna, Austria.
14MRC Laboratory of Molecular Biology, Cambridge, UK. mg@mrc-lmb.cam.ac.uk.
15MRC Laboratory of Molecular Biology, Cambridge, UK. scheres@mrc-lmb.cam.ac.uk.
#Contributed equally.

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