Members

Research Focus

Our laboratory aims to visualize and understand the brain in health and disease at the cellular and molecular levels. To this end, we have developed original technologies such as SLENDR (Cell, 2016) and vSLENDR (Neuron, 2017), which enable genome editing in single cells in the brain to visualize the localization and dynamics of endogenous proteins. We have also developed single-cell synaptome mapping (Nat Commun, 2025a), a method for analyzing thousands of synapses within single neurons, and SeeThrough (Nat Commun, 2025b), a skull-clearing technique for minimally-invasive, high-resolution in vivo brain imaging. By using these technologies, we aim to uncover the mechanisms of brain functions such as learning and memory and to better understand neurological diseases, including Alzheimer's disease.