Research FocusNeurodegeneration such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Cerebrovascular diseases including stroke and cerebral hemorrhage, as well as Developmental disorders and Mental illnesses, present significant challenges in terms of treatment and management. Many of these disorders and disabilities have a high incidence rate and are of utmost importance both in medicine and in society.
Brain disorders may be perceived as highly complex and unique to humans. However, various organisms naturally develop brain disorders through aging or other processes similar to humans. For instance, our laboratory has revealed that African killifish exhibit a disease state reminiscent of Parkinson's disease during aging, leading to numerous insights that contribute to the understanding of novel pathological mechanisms in this disorder. Cognitive impairment in various animals is also occasionally reported in news and scientific articles. Furthermore, α-synuclein, a molecular factor implicated in Parkinson's disease, is found in fish, and the amyloid precursor protein, a molecular factor in Alzheimer's disease, exists in fish and insects as well. In our laboratory, we integrate the study of various research subjects, primarily focusing on small fish species. We combine the cutting-edge neuroscience and evolutionary approaches, leveraging the esteemed Brain Bank of our institute, and employing research methodologies that cannot be replicated by AI for the next 20 to 50 years. We strive to unravel the evolutionary origins of brain disorders and establish a fundamental understanding of the pathophysiology rooted in the comprehension of the physiological functions of molecular factors that underlie these disorders.
1. Conquering difficult diseases.
2. Supporting individuals with disabilities.
3. Leaving a significant mark on the history of science.
By shedding light on the essence of brain disorders, we aim to expand our research achievements to areas such as industry-academia collaboration, drug development research, and preventive medicine, making substantial contributions to the treatment of brain disorders and the promotion of healthy longevity. Furthermore, we actively propose approaches to foster coexistence with disabilities and aging.