Pathological Neuroscience BranchDepartment of Pathology

Department Website

Members

Prof.
Akiyoshi KAKITA
Assoc. Prof.
Hiroshi SHIMIZU
Assist. Prof.
Asa NAKAHARA
Specially Appointed Assist. Prof.
Hideomi HAMASAKI
Specially Appointed Assist. Prof.
Yutaka INOUE

Research Focus

Mission

To provide the highest quality pathology services and scientific evidence focused on the advancement of developments in the field of neuropathology.

Vision

As an academic pathology department, we aim to deliver a high degree of professionalism in clinicopathological diagnostic services and neuropathology research, utilizing comprehensive and innovative approaches and building departmental competence to meet the needs of patients, institutions, and society.

Our approach will involve taking full advantage of opportunities to advance both the science and practice of neuropathology through individual and collaborative research, which hopefully will produce leading practitioners and researchers.

Charcot-Marie-Tooth disease type 2A2 (CMT2A2) is the second most common type of CMT, characterized by axonal neuropathy and optic atrophy. It is caused by mutations in the mitofusin2 (MFN2), which encodes a component of the outer mitochondrial membrane. Although a number of clinical studies have been reported, the neuropathologic features remain unknown. We have reported clinicopathologic features and mitochondrial ultrastructural abnormalities of two autopsied patients with CMT2A2.
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