Pathological Neuroscience BranchDepartment of Pathology

Department Website

Members

Prof.
Akiyoshi KAKITA
Assoc. Prof.
Hiroshi SHIMIZU
Assist. Prof.
Asa NAKAHARA
Specially Appointed Assist. Prof.
Hideomi HAMASAKI
Specially Appointed Assist. Prof.
Yutaka INOUE

Research Focus

Mission

To provide the highest quality pathology services and scientific evidence focused on the advancement of developments in the field of neuropathology.

Vision

As an academic pathology department, we aim to deliver a high degree of professionalism in clinicopathological diagnostic services and neuropathology research, utilizing comprehensive and innovative approaches and building departmental competence to meet the needs of patients, institutions, and society.

Our approach will involve taking full advantage of opportunities to advance both the science and practice of neuropathology through the Lab-specific and collaborative research, which hopefully will produce leading practitioners and researchers.

Multiple system atrophy (MSA) is a neurodegenerative disease characterized by cerebellar ataxia, parkinsonism, and autonomic dysfunction caused by α-synuclein accumulation and degeneration in the olivopontocerebellar, striatonigral, and autonomic systems. Although asymmetric symptoms are not uncommon, identifying the pattern of α-synuclein accumulation and degeneration has been difficult because these systems are usually far advanced at autopsy. We report a patient with late-onset MSA who showed marked asymmetry of degeneration in the olivopontocerebellar system, suggesting retrograde progression along the olivopontocerebellar tract.
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