The Brain Research Institute at Niigata University traces its origins to the Niigata University Brain Research Laboratory, founded through the dedication of Professor Mizuho Nakata and other pioneering researchers. Since its establishment in 1967, the Institute has carried out its activities for more than half a century. From its earliest days, a defining characteristic of the Institute has been the integration of clinically oriented departments－neurosurgery, neurology, and pathology－within a single research organization, a distinctive feature that continues to shape its identity today.
Our research has consistently centered on the human brain and brain diseases. Researchers from diverse backgrounds have come together, united by a shared interest in understanding abnormalities of the human brain and in striving to overcome them. We place no limitations on research methodologies. By integrating clinical studies, pathology, imaging, genetic and molecular biology, analyses using model organisms, and research that approaches brain disorders from an evolutionary perspective, we aim to achieve a multifaceted understanding of brain pathology.
One of the Institute's greatest strengths is its environment in which researchers from different disciplines engage in daily discussions and collaborate across fields. By connecting molecular-level changes to phenomena observed in individuals and entire populations, we pursue fundamental questions such as: "What mechanisms underlie brain diseases?" and "Why do such diseases exist in the first place?"
Brain tissue donated through the generous and profoundly meaningful decisions of patients, their families, and healthcare professionals forms a vital foundation supporting our research. By carefully managing and responsibly utilizing these invaluable contributions, we have been able to connect basic research with clinical studies, deepen our understanding of human brain diseases, and advance the search for effective solutions.
In April 2026, the Institute will undergo organizational restructuring and enter a new phase of brain research under a renewed framework. Building on the integration of clinical, pathological, and basic research developed over many years, we will further embrace new perspectives－including evolutionary biology, rapidly advancing molecular biology, data science and artificial intelligence, and cutting-edge neuroscience. Through this expansion, we aim to create a more flexible, open, and forward-looking research institute for the future.
At the same time, we consider it a vital mission to return our research outcomes to society, to educate and nurture the next generation of researchers and students, and to create new value through collaboration with industry and local communities. In addition to advancing research aimed at overcoming brain diseases, we seek to contribute to shaping a society that supports healthy, fulfilling lives for people living with disability and aging.
With deep respect for the aspirations entrusted to us, all members of the Institute remain committed to pursuing these goals with sincerity and dedication. We sincerely appreciate your continued understanding and support of the Brain Research Institute, Niigata University.
