Research Findings

2025.06.02

Association of rare APOE missense variants with Alzheimer's disease in the Japanese population

J Alzheimers Dis. 2025 May 21:13872877251340710. doi: 10.1177/13872877251340710. Online ahead of print.

Miyashita A1, Obinata A1, Hara N1, Mitsumori R2, Kaneda D3, Hashizume Y3, Sano T4, Takao M4, Gabdulkhaev R5, Tada M6, Kakita A5, Arakawa A7, Morishima M7, Murayama S7,8, Saito Y7, Hatsuta H9,10, Matsubara T7, Akagi A11, Riku Y11, Miyahara H11, Sone J11, Yoshida M11, Yamaguchi H12, Tsukie T1, Hasegawa M1, Kasuga K1, Kikuchi M1, Akatsu H13, Kuwano R14, Iwatsubo T15,16,17; Japanese Alzheimer's Disease Neuroimaging Initiative17; Niida S18, Ozaki K2,19, Ikeuchi T1.

  1. Department of Molecular Genetics, Brain Research Institute, Niigata University
  2. Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology
  3. Department of Neuropathology, Fukushimura Hospital
  4. Department of Clinical Laboratory and Internal Medicine, National Center of Neurology and Psychiatry (NCNP), National Center Hospital
  5. Department of Pathology, Brain Research Institute, Niigata University
  6. Department of Pathology Neuroscience, Brain Research Institute, Niigata University
  7. Department of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology
  8. Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University
  9. Department of Neurology, Osaka Metropolitan University Graduate School of Medicine
  10. Hatsuta Neurology Clinic
  11. Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University
  12. Professor Emeritus, Gunma University
  13. Center for Frailty and Locomotive Syndrome, National Center for Geriatrics and Gerontology
  14. Social Welfare Corporation Asahigawaso, Asahigawaso Research Institute
  15. Department of Neuropathology, Graduate School of Medicine, The University of Tokyo
  16. Director's Office, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)
  17. Japanese Alzheimer's Disease Neuroimaging Initiative
  18. Research Institute, National Center for Geriatrics and Gerontology
  19. RIKEN Center for Integrative Medical Sciences

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