2016.05.24
Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL
Hiroaki Nozaki, MD, PhD*, Taisuke Kato, PhD*, Megumi Nihonmatsu, MMed, Yohei Saito, MMed,Ikuko Mizuta, MD, PhD, Tomoko Noda, MD, Ryoko Koike, MD, PhD, Kazuhide Miyazaki, MD, Muichi Kaito, MD, PhD, Shoichi Ito, MD, PhD, Masahiro Makino, MD, PhD, Akihide Koyama, MMed, Atsushi Shiga, PhD, Masahiro Uemura, MD, Yumi Sekine, MD, PhD, Ayuka Murakami, MD, Suzuko Moritani, MD, PhD, Kenju Hara, MD, PhD, Akio Yokoseki, MD, PhD, Ryozo Kuwano, MD, PhD, Naoto Endo, MD, PhD, Takeshi Momotsu, MD, Mari Yoshida, MD, PhD, Masatoyo Nishizawa, MD, PhD, Toshiki Mizuno, MD, PhD and Osamu Onodera, MD, PhD
From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics, Bioresource Science Branch, Brain Research Institute (R. Kuwano), Niigata University, Niigata City; Department of Neurology (I.M., T. Mizuno), Kyoto Prefectural University of Medicine; Department of Neurology (T.N.), Ichinomiya Municipal Hospital, Aichi; Department of Neurology (R. Koike), Nishi-Niigata Chuo National Hospital, Niigata; Department of Neurology (K.M.), Shiseikai-Daini Hospital, Tokyo; Department of Neurology (M.K.), Kanazawa Medical University, Ishikawa; Department of Neurology (S.I.), Chiba University; Department of Neurology (M.M.), Nantan General Hospital, Kyoto; Departments of Neurology (A.M.) and Advanced Diagnosis (S.M.), Nagoya Medical Center, Aichi; Department of Neurology (K.H.), Japanese Red Cross Akita Hospital; Department of Internal Medicine (T. Momotsu), Sado General Hospital, Niigata; and Institute for Medical Science of Aging (M.Y.), Aichi Medical University, Japan.
