Members
Atsushi SUGIE
Jiro OSAKA
Research Focus
In our laboratory, we focus on 'elucidating the mechanisms of neuronal robustness' and 'contributing to the study of neurological disorders.' Our research explores how neurons withstand excessive activity and how this resilience changes in neurodegenerative conditions. As part of this research, we have developed a model of neuronal hyperactivity in the optic neurons of fruit flies induced by light stimulation, and have elucidated its pathological mechanisms. Furthermore, we have developed an automated quantification program using machine learning, 'MeDUsA,' advancing the identification and understanding of molecules related to the robustness of neurons. Additionally, by utilizing fruit flies, we have clarified the pathological significance of genetic mutations, contributing to the research of rare diseases and autosomal dominant optic atrophy, among other neurological disorders. The use of fruit flies allows us to efficiently test the effects of many unexplored genetic mutations, even within time and budget constraints. The simplicity and rapid genetic analysis of fruit flies complement human disease research and have the potential to lead to the development of new treatments. We aim to serve as a bridge between basic and clinical research, contributing to the understanding of neurological survival mechanisms, advancing our knowledge of neurological diseases, and aiding in diagnosis.