杉江先生

Member

Assoc. Prof.
Atsushi SUGIE

Specially Appointed Assist. Prof.
Yohei NITTA

Specially Appointed Assist. Prof.
Jiro OSAKA

Research Focus

Neural circuits of the brain usually maintain their function over a long duration; therefore, it is believed that circuit-forming neurons sustain a long-term health-maintenance mechanism via unique cellcell interactions, unlike somatic cells that preserve tissue health via cell turnover. Disruption of this circuit-maintenance mechanism could lead to aging, neurodegenerative diseases, and mental disorders. However, intercellular communication mechanism to maintain neuronal health has not been fully elucidated owing to such an investigation being time consuming. We overcome this complication by taking advantage of the short life cycle and rarely duplicated genes of Drosophila that enable rapid genetic analyses. We are conducting research that focuses on synapses that serve as transmission sites for neuronal information. Further studies are also being undertaken to investigate the metabolism of the phospholipids that constitute the cell membranes between adjacent cells. From these studies, we expect to propose novel findings on the molecular basis of neuroprotection through regulation of synapse transmission and lipid metabolism.

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