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Research Focus

Current biopsy and histology have long relied on thin-sectioned 2D images with several chemical staining methods and specific immunohistochemistry. Facile 3D visualization of human brain tissue with single-cell resolution would provide a novel concept of the neuropathological diagnosis and contribute our understanding of pathological mechanisms based on comprehensive and quantitative analysis of individual biomarker. In this laboratory, we aim at establishing a novel 3D neuropathology by developing a highly efficient clearing protocol for human brain tissue and combining with a rapid 3D imaging using light-sheet fluorescence microscopy.