Structural and metabolic signatures of cardiac aging in African turquoise killifish (Nothobranchius furzeri) Histol. Histopathol. , 2026.
Publications
2026
Research articles
A protective role for APP in nuclear waste clearance via lysosomal exocytosis Proc. Natl. Acad. Sci. USA 123(24) : e2524190123 , 2026.
↳ Highlighted in PNAS Commentary: Thangavel, M., Masurkar, A. V. Nuclear garbage disposal: An unexpected role for amyloid precursor protein in Alzheimer’s disease. Proc. Natl. Acad. Sci. USA, 2026. doi:10.1073/pnas.2619791123
A cost-effective method to assess light/dark preference and activity in zebrafish larvae Heliyon 12(4) : e44675 , 2026.
Crosstalk between ApoE-expressing cells and genotoxic stress in the mouse brain Brain Res. 1871 : 150080 , 2026.
Reviews
Loss of tissue-state plasticity: a conceptual framework for age-associated regenerative failure Inflamm. Regener. 46 : 37 , 2026.
2025
Research articles
Behavioral and molecular insights into anxiety in ube3a and fmr1 zebrafish models of autism spectrum disorders Transl. Psychiatry 15(1) : 512 , 2025.
Mutation of ube3a causes developmental abnormalities and autism-like molecular and behavioral alterations in zebrafish Brain Res. Bull. 231 : 111542 , 2025.
A robust protocol for proteomic profiling of secreted proteins in conditioned culture medium Biol. Methods Protoc. 10(1) : bpaf068 , 2025.
Lipofuscin autofluorescence confounds intracellular amyloid β detection in the aged mouse brain Aging Brain 8 : 100148 , 2025.
Environmental context modulates sociability in ube3a zebrafish mutants via alterations in sensory pathways Mol. Psychiatry 31(1) : 158-172 , 2026. Published online 26 August 2025.
Listed under 2025, the year of online publication. The journal issue is dated 2026.
Phosphorylation of optineurin by TBK1 drives fragmentation of Golgi apparatus Biochem. Biophys. Res. Commun. 752 : 151447 , 2025.
Reviews
Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease Transl. Neurodegener. 14(1) : 67 , 2025.
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs Mech. Ageing Dev. 226 : 112087 , 2025.
Exploring α-Syn’s Functions Through Ablation Models: Physiological and Pathological Implications Cell. Mol. Neurobiol. 45(1) : 44 , 2025.
Three decades of neuroscience research using animal models of ADHD and ASD: a bibliometric analysis Front. Psychiatry 16 : 1528205 , 2025.
2024
Research articles
Homozygous slc25a20 zebrafish mutant reveals insights into carnitine-acylcarnitine translocase deficiency pathogenesis Mol. Genet. Metab. Rep. 41 : 101165 , 2024.
Single housing of juveniles accelerates early-stage growth but extends adult lifespan in African turquoise killifish Aging 16(18) : 12443-12472 , 2024.
The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development J. Biol. Chem. 300(2) : 105629 , 2024.
GPATCH4 contributes to nucleolus morphology and its dysfunction impairs cell viability Biochem. Biophys. Res. Commun. 693 : 149384 , 2024.
Reviews
Current trends in basic research on Parkinson's disease: from mitochondria, lysosome to α-synuclein J. Neural Transm. 131(6) : 663-674 , 2024.
Modeling familial and sporadic Parkinson's disease in small fishes Dev. Growth Differ. 66(1) : 4-20 , 2024.
Japanese-language reviews
神経変性疾患と細胞老化 [Neurodegeneration and cellular senescence] [Japanese-language review] 実験医学増刊「細胞老化―真の機能を深く理解する」 42(20) : 197-203 , 2024.
2023
Research articles
Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease Proc. Natl. Acad. Sci. USA 120(23) : e2214652120 , 2023.
Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner Front. Mol. Neurosci. 16 : 1166900 , 2023.
Reviews
Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders Int. J. Mol. Sci. 24(8) : 7079 , 2023.
Japanese-language reviews
動物の多様な脳をモデルとした疾患研究 [Disease research using diverse animal brains as models] [Japanese-language review] Clinical Neuroscience 41(12) : 1611-1615 , 2023.
2022
Research articles
The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders Front. Genet. 13 : 928597 , 2022.
Rapid reverse genetics systems for Nothobranchius furzeri, a suitable model organism to study vertebrate aging Sci. Rep. 12 : 11628 , 2022.
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration NeuroReport 33(7) : 320-325 , 2022.
Evaluation of Ectopic Mitochondrial DNA in HeLa Cells Curr. Issues Mol. Biol. 44(3) : 1215-1223 , 2022.
Reviews
Glutamatergic pathways in the brains of turtles: A comparative perspective among reptiles, birds, and mammals Front. Neuroanat. 16 : 937504 , 2022.
Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish Int. J. Mol. Sci. 23(14) : 7550 , 2022.
Zebrafish, Medaka and Turquoise Killifish for Understanding Human Neurodegenerative/Neurodevelopmental Disorders Int. J. Mol. Sci. 23(3) : 1399 , 2022.
Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson's disease Neural Regen. Res. 17(12) : 2682-2684 , 2022.
Perspective
Japanese-language reviews
異所性核酸 [Ectopic nucleic acids] [Japanese-language review] 生化学 94(6) : 929 , 2022.
ミトコンドリアDNAの漏出が引き起こす細胞死 [Cell death caused by leakage of mitochondrial DNA] [Japanese-language review] 生化学 94(5) : 696-700 , 2022.
2021
Research articles
Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease Nat. Commun. 12(1) : 3101 , 2021.
Esophageal High-Resolution Manometry for Diagnosing the Severity of the Chronic Intestinal Pseudo-Obstruction: A Case Series Dig. Dis. Sci. 66(11) : 3960-3967 , 2021.
Japanese-language reviews
小型魚類で明らかにする生老病死 [Life, aging, disease and death as seen in small fishes] [Japanese-language review] 新潟医学会雑誌 135(8) : 143-148 , 2021.
細胞質に漏出したmtDNAが惹起するパーキンソン病の神経変性 [Parkinson's neurodegeneration driven by cytosolic mtDNA] [Japanese-language review] 実験医学 39(16) , 2021.
2020
Research articles
Degeneration of dopaminergic neurons and impaired intracellular trafficking in Atp13a2 deficient zebrafish IBRO Rep. 9 : 1-8 , 2020.
Japanese-language reviews
小型魚類を用いた医学研究 [Medical research using small fishes] [Japanese-language review] 新潟県医師会報 10(847) : 2-6 , 2020.
2019
Research articles
Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy Auton. Neurosci. 221 : 102583 , 2019.
Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri Cell Rep. 26(7) : 1727-1733.e6 , 2019.
2018
Reviews
Parkinson's disease pathogenesis from the viewpoint of small fish models J. Neural Transm. 125(1) : 25-33 , 2018.
Japanese-language reviews
パーキンソン病という病気 その1 [Parkinson's disease, part 1] [Japanese-language review] 脳研究所コラム , 2018.
αシヌクレインとそのリン酸化 [α-Synuclein and its phosphorylation] [Japanese-language review] Medical Science Digest 44(3) : 66-67 , 2018.
パーキンソン病はリソソーム異常が原因である:「Yes」の立場から [Parkinson's disease is caused by lysosomal dysfunction: the 'Yes' position] [Japanese-language review] Frontiers in Parkinson Disease 11(2) : 78-81 , 2018.
アフリカメダカは老化とともにパーキンソン病に罹患する [The African killifish develops Parkinson's disease with aging] [Japanese-language review] 新潟医学会雑誌 132(5) : 166-180 , 2018.
Book chapters
興奮毒性 [Excitotoxicity] [in Japanese] 日本臨床 パーキンソン病(第2版)—基礎・臨床研究のアップデート— : 162-166 , 2018.
小型魚類を利用したパーキンソン病モデル [Small-fish models of Parkinson's disease] [in Japanese] 別冊・医学のあゆみ パーキンソン病の新展開—発症の分子機構と新規治療 : 53-58 , 2018.
2017
Research articles
Cerebrospinal fluid injection into adult zebrafish for disease research J. Neural Transm. 124(12) : 1627-1633 , 2017.
An optimized method for counting dopaminergic neurons in zebrafish PLoS One 12(9) : e0184363 , 2017.
Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light J. Vis. Exp. (120) : 55176 , 2017.
Reviews
Dopamine system, cerebellum, and nucleus ruber in fish and mammals Dev. Growth Differ. 59(4) : 219-227 , 2017.
The use of fish models to study human neurological disorders Neurosci. Res. 120 : 1-7 , 2017.
Japanese-language reviews
小型魚類を利用したパーキンソン病モデル [Small-fish models of Parkinson's disease] [Japanese-language review] 医学のあゆみ 262(6) : 635-640 , 2017.
生命科学を開く新しい実験動物モデル-11. 超短命脊椎動物アフリカメダカ [A new experimental animal for life science, 11: the extremely short-lived vertebrate Nothobranchius furzeri] [Japanese-language review] 生体の科学 68(1) : 80-84 , 2017.
Book chapters
小型魚類を用いた神経精神疾患研究 [Neuropsychiatric disease research in small fishes] [in Japanese] ブレインサイエンス・レビュー2017 : 253-270 , 2017.
2016
Editorials and discussions
座談会 パーキンソン病の動物モデル―最近の話題 [Discussion: animal models of Parkinson's disease] [in Japanese] Frontiers in Parkinson's Disease 9(1) : 5-13 , 2016.
2015
Research articles
Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles Dev. Dyn. 244(12) : 1574-1580 , 2015.
Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein PLoS Genet. 11(4) : e1005065 , 2015.
Japanese-language reviews
パーキンソン病の小型魚類モデル [Small-fish models of Parkinson's disease] [Japanese-language review] BIO Clinica 30(9) : 757-760 , 2015.
2014
Research articles
Identification of the zebrafish red nucleus using Wheat Germ Agglutinin transneuronal tracing Commun. Integr. Biol. 7(6) : e994383 , 2014.
Functional regionalization of the teleost cerebellum analyzed in vivo Proc. Natl. Acad. Sci. USA 111(32) : 11846-11851 , 2014.
↳ Highlighted in PNAS Commentary: Okamoto, H. Minicerebellum, now available for reductionists’ functional study. Proc. Natl. Acad. Sci. USA, 2014. doi:10.1073/pnas.1411821111
Reviews
Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish Journal of Parkinson's Disease 4(2) : 301-310 , 2014.
2013
Research articles
ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons FEBS Lett. 587(9) : 1316-1325 , 2013.
PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates Hum. Mol. Genet. 22(12) : 2423-2434 , 2013.
TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency Ann. Neurol. 74(6) : 837-847 , 2013.
2012
Reviews
Medaka Fish Parkinson's Disease Model Exp. Neurobiol. 21(3) : 94-100 , 2012.
2010
Research articles
Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish J. Neurochem. 115(5) : 1150-1160 , 2010.
Proteasome inhibition in medaka brain induces the features of Parkinson's disease J. Neurochem. 115(1) : 178-187 , 2010.
Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement Neurosci. Res. 66(2) : 151-161 , 2010.
2009
Research articles
A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish Neurosci. Res. 65(3) : 263-271 , 2009.
Japanese-language reviews
パーキンソン病の発症機構 [Pathogenesis of Parkinson's disease] [Japanese-language review] Brain and Nerve 61(4) : 441-446 , 2009.
2008
Japanese-language reviews
キーワード 蛋白質の一生:パーキンソン病 [Keyword: the life of proteins — Parkinson's disease] [Japanese-language review] 蛋白質核酸酵素 53(8) : 981 , 2008.
2007
Research articles and case reports
Thalamic Hyperperfusion in Verbal Hallucination of Parkinsonian Patients Intern. Med. 46(21) : 1765-1769 , 2007.
Auditory event-related potentials in Parkinson's disease: Prominent correlation with attention Parkinsonism Relat. Disord. 13(7) : 394-398 , 2007.
Heterogeneous factors in dementia with Parkinson's disease: IMP-SPECT study Parkinsonism Relat. Disord. 13(3) : 174-181 , 2007.
Depression in Parkinson's disease J. Neurol. 254(9) : 1170-1173 , 2007.
Trousseau Syndrome Due to Pleural Mesothelioma Neurologist 13(4) : 205-208 , 2007.
Dementia in Parkinson's disease: diffusion tensor imaging Acta Neurol. Scand. 116(3) : 177-181 , 2007.
Japanese-language reviews
パーキンソン病関連遺伝子:PINK1、DJ-1、LRRK2 [Parkinson's disease genes: PINK1, DJ-1, LRRK2] [Japanese-language review] 実験医学 25(13) : 1969-1973 , 2007.
2006
Research articles and case reports
Adult onset hemiparkinsonism with brain hemihypoplasia Neurol. India 54(4) : 450-451 , 2006.
Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations Mov. Disord. 21(12) : 2140-2144 , 2006.
Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations Mov. Disord. 21(12) : 2165-2169 , 2006.
Excessive Daytime Sleepiness in Parkinson Disease: A SPECT Study Sleep 29(7) : 917-920 , 2006.
Wisconsin Card Sorting Test and brain perfusion imaging in Parkinson's disease Parkinsonism Relat. Disord. 12(5) : 273-278 , 2006.
Minor depression and brain perfusion images in Parkinson's disease Mov. Disord. 21(8) : 1169-1174 , 2006.
Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease correlate with major autonomic symptoms? Parkinsonism Relat. Disord. 12(5) : 284-288 , 2006.
Disruptions of the fornix fiber in parkinsonian patients with excessive daytime sleepiness Parkinsonism Relat. Disord. 12(5) : 319-322 , 2006.
HTLV-I-Associated Peripheral Neuropathy With Smoldering-Type Adult T-Cell Leukemia Neurologist 12(2) : 109-113 , 2006.
Frontal Assessment Battery and Brain Perfusion Image in Parkinson's Disease J. Geriatr. Psychiatry Neurol. 19(1) : 41-45 , 2006.
Encephalopathy and severe neuropathy due to probable systemic vasculitis as an initial manifestation of mixed connective tissue disease Neurol. India 54(1) : 83-85 , 2006.
Parkinson's Disease Following Panic Disorder The Journal of Neuropsychiatry and Clinical Neurosciences 18(1) : 130-130 , 2006.
Impaired Visual Acuity as a Risk Factor for Visual Hallucinations in Parkinson's Disease J. Geriatr. Psychiatry Neurol. 19(1) : 36-40 , 2006.
2005
Research articles and case reports
Multiple Sclerosis Following Splenectomy as a Treatment for Idiopathic Thrombocytopenic Purpura Intern. Med. 44(7) : 747-749 , 2005.
The Relation Between Visual Hallucinations and Visual Evoked Potential in Parkinson Disease Clin. Neuropharmacol. 28(2) : 79-82 , 2005.
Persistent Primitive Hypoglossal Artery with Atrial Septal Defect Intern. Med. 44(5) : 507-508 , 2005.
Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease Mov. Disord. 20(10) : 1272-1277 , 2005.
N-isopropyl-p-123I Iodoamphetamine Single Photon Emission Computed Tomography Study of Parkinson's Disease with Dementia Intern. Med. 44(10) : 1046-1050 , 2005.
Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian features Parkinsonism Relat. Disord. 11(4) : 227-232 , 2005.
Metaiodobenzylguanidine (MIBG) scintigraphy at various parts of the body in Parkinson's disease and multiple system atrophy Auton. Neurosci. 119(1) : 56-60 , 2005.
Metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease also decreases at thyroid Ann. Nucl. Med. 19(3) : 225-229 , 2005.
2004
Case reports
POEMS Syndrome Demonstrating VEGF Decrease by Ticlopidine Intern. Med. 43(11) : 1082-1083 , 2004.