Publications

*: 責任著者
論文（英文査読付き論文）
2024年
Hishida, R., Ishiguro, K., Tomoyuki, Y., Toyokuni, S., Matsui, H.* Homozygous slc25a20 Zebrafish Mutant Reveals Insights into Carnitine-Acylcarnitine Translocase Deficiency Pathogenesis. Mol. Genet. Metab. Rep. 41:101165, 2024.

Takahashi C., Okabe E., Nono M., Kishimoto S., Matsui H., Ishitani T., Yamamoto T., Uno M., Nishida E. Single housing of juveniles accelerates early-stage growth but extends adult lifespan in African turquoise killifish. Aging., 16(18):12443-12472, 2024.

Matsui, H.*, Takahashi, R. Current trends in basic research on Parkinson's disease: from mitochondria, lysosome to α-synuclein. J. Neural. Transm., 131(6):663-674, 2024.

Yamanaka, T., Kurosawa, M., Yoshida, A., Shimogori, T., Hiyama, A., Maity, S. N., Hattori, N., Matsui, H., Nukina, N. NF-YA is Crucial for Neural Progenitor Maintenance in Brain Development. J.Biol. Chem., 300(2):105629, 2024.

Kodera, K., Hishida, R., Sakai, A., Nyuzuki, H., Matsui, N., Yamanaka, T., Saitoh, A., Matsui, H.* GPATCH4 contributes to nucleolus morphology and its dysfunction impairs cell viability. Biochem. Biophys. Res. Commun., 693:149384, 2024.

2023年
Yamanaka, T., Matsui, H.* Modeling familial and sporadic Parkinson's diseases in small fishes. Dev. Growth. Differ., 66(1):4-20, 2024.

Matsui, H.*, Ito, S., Matsui, H., Ito, J., Gabdulkhaev, R., Hirose, M., Yamanaka, T., Koyama, A., Kato, T., Tanaka, M., Uemura, N., Matsui, N., Hirokawa, S., Yoshihama, M., Shimozawa, A., Kubo, S., Iwasaki, K., Hasegawa, M., Takahashi, R., Hirai, K., Kakita, A., Onodera, O. Phosphorylation of α-Synuclein at T64 Results in Distinct Oligomers and Exerts Toxicity in models of Parkinson’s Disease. Proc. Natl. Acad. Sci. USA, 120(23):e2214652120, 2023.
プレスリリース: https://www.bri.niigata-u.ac.jp/research/result/20230601_matsui_pressrelease.pdf

Otsuka, T., Matsui, H.* Fish models for exploring mitochondrial dysfunction affecting neurodegenerative disorders. Int. J. Mol. Sci., 24(8):7079, 2023.

Dorigo, A., Valishetti, K., Hetsch, F., Matsui, H., Jochen C., Meier, J.C., Namikawa, K., Köster, R. Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner. Front. Mol. Neurosci., 16:1166900, 2023.

2022年
Mohammad, H., Sakai, A. Matsui, H.* Glutamatergic pathways in the brains of turtles: A comparative perspective among reptiles, birds, and mammals. Front. Neuroanat. 16:937504, 2022.

Dohi, E., Matsui, H.*The utility of small fishes for the genetic study of human age-related disorders. Front. Genet.13:928597, 2022.

Dougnon, G., Matsui, H.* Modelling autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) using mice and zebrafish. Int. J. Mol. Sci. 23(14):7550, 2022.

Oginuma, M., Nishida, M., Ohmura-Adachi, T., Abe, K., Ogamino, S., Mogi, C.,Matsui, H., Ishitani, T. Rapid reverse genetics systems for N. furzeri, a suitable model organism to study vertebrate aging. (preprint: https://www.researchsquare.com/article/rs-1467860/v1)からのSci. Rep.

Kodera, K.,Matsui, N., Saitoh, A.,Matsui, H.* Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein in addition does not further worsen the degeneration.Neuroreport33(7):320-325, 2022.

Mohammad, H.,Matsui, N.Matsui, H.* Evaluation of Ectopic Mitochondrial DNA in Hela Cells.Curr. Issues Mol. Biol.44(3):1215-1223, 2022.

Kodera, K.,Matsui, H.* Zebrafish, Medaka and Turquoise Killifish for Understanding Human Neurodegenerative/Neurodevelopmental Disorders.Int. J. Mol. Sci.23(3):1399, 2022.

Sakai, A.,Matsui, H.* Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson’s disease.Neural Regen. Res.17(12):2682-2684, 2022.

2021年
Matsui, H.*, Ito, J.,Matsui, N., Uechi, T., Onodera, O., Kakita, A. Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease.Nat. Commun.12(1):3101, 2021.
プレスリリース:https://www.bri.niigata-u.ac.jp/research/result/210521.research_findings.pdf
EurekAlert!(英語プレスリリース):https://www.eurekalert.org/pub_releases/2021-06/nu-nsg061021.php
JST英語プレスリリース:https://sj.jst.go.jp/news/202108/n0812-04k.html

2020年
Sato, H., Kamimura, K.,Matsui, H., Owaki, T., Morita, S., Tanaka, Y., Ishikawa, N., Shimada, Y., Yokoyama, J., Wakai, T., Terai, S. Esophageal High-resolution Manometry for Diagnosing the Severity of the Chronic Intestinal Pseudo-obstruction: A Case Series.Digest. Dis. Sci.66(11):3960-3967, 2021.

Nyuzuki, H., Ito, S., Nagasaki, K., Nitta, Y.,Matsui, N., Saitoh, A.,Matsui, H.* Degeneration of dopaminergic neurons and impaired intracellular trafficking in Atp13a2 deficient zebrafish.IBRO Rep9:1-8, 2020.

2019年
Ozawa, T., Shimizu, H.,Matsui, H., Onodera, O., Kakita, A. Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy.Autonomic Neuroscience: Basic and Clinical221:102583, 2019.

Matsui, H.*, Kenmochi, N., Kazuhiko, N. Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.Cell Rep26(7):1727-1733, 2019.

2018年
Matsui, H.*, Ryosuke, T. Parkinson’s Disease pathogenesis from the viewpoint of small fish models.J Neural Transm125(1):25-33, 2018.

2017年
Matsui, H.*,Matsui, N.Cerebrospinal fluid injection into adult zebrafish for disease research.J Neural Transm124(12):1627-1633, 2017.

Matsui, H.*, Sugie, A. An optimized method for counting dopaminergic neurons in zebrafish.Plos One12(9): e0184363, 2017.

Matsui, H.* Dopamine system, cerebellum, and nucleus ruber in fish and mammals.Dev Growth Differ59(4): 219-227, 2017.

Matsui, H.* The Use of Fish Models to Study Human Neurological Disorders.Neurosci Res120: 1-7, 2017. (Cover article)

Sugie, A., Möhl, C., Hakeda-Suzuki, S.,Matsui, H., Suzuki, T., Tavosanis, G. Analyzing synaptic modulation of Drosophila photoreceptors after exposure to prolonged light.J Vis Exp120, 2017.

2015年
Matsui, H., Dorigo, A., Buchberger, A., Hocking, J.C., Distel, M., Köster, R.W. Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles.Dev Dyn244(12): 1574-1580, 2015.

Uemura, N., Koike, M., Ansai, S., Kinoshita, M., Ishikawa-Fujiwara, T.,Matsui, H., Naruse, K., Sakamoto, N., Uchiyama, Y., Todo, T., Takeda, S., Yamakado, H., and Takahashi, R. Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein.Plos Genet11(4): e1005065, 2015.

2014年
Matsui, H.*, Namikawa, K., and Köster, R. Identification of the zebrafish red nucleus using Wheat Germ Agglutinin transneuronal tracing.Commun Integr Biol7(6): e994383, 2014.

Matsui, H.*, Namikawa, K., Babaryka, A. and Köster, R. Functional regionalization of the teleost cerebellum analyzed in vivo.Proc Natl Acad Sci USA111(32): 11846-11851, 2014. (Cover article)

Matsui, H.*, Uemura, N., Yamakado, H., Takeda, S., and Takahashi, R. Exploring the Pathogenetic Mechanisms underlying Parkinson’s Disease using Medaka Fish.J Parkinsons Dis4(2): 301-310, 2014.

2013年
Matsui, H., Sato, F., Sato, S., Koike, M., Taruno Y., Saiki, S., Funayama, M., Ito, H., Taniguchi, Y., Uemura N., Toyoda, A., Sakaki, Y., Takeda, S., Uchiyama, Y., Hattori, N. and Takahashi, R. ATP13A2 Deficiency Induces a Decrease in Cathepsin D Activity, Fingerprint-like Inclusion Body Formation and Selective Degeneration of Dopaminergic Neurons.FEBS Lett587(9): 1316-1325, 2013.

Matsui, H.*, Gavinio, R., Asano T, Uemura N., Ito, H., Taniguchi, Y., Kobayashi Y., Maki, T., Shen J., Hattori, N., Takeda, S., Uemura K., Yamakado H. and Takahashi, R. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.Hum Mol Genet22(12): 2423-2434, 2013.

Flinn, L.J., Keatinge, M., Bretaud, S., Mortiboys, H.,Matsui, H., De Felice, E., Woodroof, H.I., Brown, L., McTighe, A., Soellner, R., Allen, C.E., Heath, P.R., Milo, M., Muqit, M.M., Reichert, A.S., Köster, R.W., Ingham, P.W. and Bandmann, O. TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.Ann Neurol74(6): 837-847, 2013.

2012年
Matsui, H.,* Gavinio, R., and Takahashi, R. Medaka fish Parkinson’s disease model.Neurobiol21(3): 94-100, 2012.

2010年
Matsui, H., Ito, H., Taniguchi, Y., Takeda, S. and Takahashi, R. Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson’s disease-like phenotypes in medaka fish.J Neurochem115(5): 1150-1160, 2010.

Matsui, H., Ito, H., Taniguchi, Y., Inoue, H., Takeda, S. and Takahashi, R. Proteasome inhibition in medaka brain induces the features of Parkinson’s disease.J Neurochem115(1): 178-187, 2010.

Matsui, H., Taniguchi, Y., Inoue, H., Kobayashi, Y., Sakaki, Y., Toyoda, A., Uemura, K., Kobayashi, D., Takeda, S. and Takahashi, R. Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement.Neurosci Res66(2): 151-161, 2010.

2009年
Matsui, H., Taniguchi, Y., Inoue, H., Uemura, K., Takeda, S. and Takahashi, R. A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish.Neurosci Res65(3): 263-271, 2009.

2007年
Matsui, H.*, Nishinaka, K., Miyoshi, T., Hara, N., Oda, M., Kubori, T. and Udaka, F. Thalamic hyperperfusion in verbal hallucination of Parkinsonian patients.Intern Med46(21): 1765-1769, 2007.

Matsui, H.*, Nishinaka, K., Oda, M., Kubori, T. and Udaka, F. Auditory event-related potentials in Parkinsons disease: prominent correlation with attention.Parkinsonism Relat Disord13(7): 394-398, 2007.

Matsui, H.*, Nishinaka, K., Oda, M., Hara, N., Komatsu, K., Kubori, T. and Udaka, F. Heterogeneous factors in dementia with Parkinsons disease: IMP-SPECT study.Parkinsonism Relat Disord13(3): 174-181, 2007.

Matsui, H.*, Nishinaka, K., Oda, M., Niikawa, H., Komatsu, K., Kubori, T. and Udaka, F. Depression in Parkinsons disease. Diffusion tensor imaging study.J Neurol254(9): 1170-1173, 2007.

Matsui, H.*, Nishinaka, K., Oda, M., Kubori, T. and Udaka, F. Trousseau syndrome due to pleural mesothelioma.Neurologist13(4): 205-208, 2007.

Matsui, H.*, Nishinaka, K., Oda, M., Niikawa, H., Komatsu, K., Kubori, T. and Udaka, F. Dementia in Parkinson's disease: diffusion tensor imaging.Acta Neurologica Scandinavica116(3): 177-181, 2007.

2006年
Matsui, H.*, Nishinaka, K., Oda, M., Komatsu, K., Kubori, T. and Udaka, F. Adult onset hemiparkinsonism with brain hemihypoplasia.Neurol India54(4): 450-451, 2006.

Matsui, H.*, Nishinaka, K., Oda, M., Hara, N., Komatsu, K., Kubori, T. and Udaka, F. Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations.Mov Disord21(12): 2140-2144, 2006.

Matsui, H.*, Nishinaka, K., Oda, M., Hara, N., Komatsu, K., Kubori, T. and Udaka, F. Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations.Mov Disord21(12): 2165-2169, 2006.

Matsui, H.*, Nishinaka, K., Oda, M., Hara, N., Komatsu, K., Kubori, T. and Udaka, F. Excessive daytime sleepiness in Parkinson disease: a SPECT study.Sleep29(7): 917-920, 2006.

Matsui, H.*, Nishinaka, K., Oda, M., Hara, N., Komatsu, K., Kubori, T. and Udaka, F. Wisconsin Card Sorting Test and brain perfusion imaging in Parkinsons disease.Parkinsonism Relat Disord12(5): 273-278, 2006.

Matsui, H.*, Nishinaka, K., Oda, M., Komatsu, K., Kubori, T. and Udaka, F. Minor depression and brain perfusion images in Parkinsons disease.Mov Disord21(8): 1169-1174, 2006.

Matsui, H.*, Nishinaka, K., Oda, M., Komatsu, K., Kubori, T. and Udaka, F. Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinsons disease correlate with major autonomic symptoms?.Parkinsonism Relat Disord12(5): 284-288, 2006.

Matsui, H.*, Nishinaka, K., Oda, M., Niikawa, H., Komatsu, K., Kubori, T. and Udaka, F. Disruptions of the fornix fiber in Parkinsonian patients with excessive daytime sleepiness.Parkinsonism Relat Disord12(5): 319-322, 2006.

Matsui, H.*, Udaka, F., Kubori, T., Oda, M., Nishinaka, K. and Oka, N. HTLV-I-associated peripheral neuropathy with smoldering-type adult T-cell leukemia.Neurologist12(2): 109-113, 2006.

Matsui, H.*, Udaka, F., Miyoshi, T., Hara, N., Tamura, A., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. Frontal assessment battery and brain perfusion image in Parkinsons disease.J Geriatr Psychiatry Neurol19(1): 41-45., 2006.

Matsui, H.*, Udaka, F., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. Encephalopathy and severe neuropathy due to probable systemic vasculitis as an initial manifestation of mixed connective tissue disease.Neurol India54(1): 83-85, 2006.

Matsui, H.*, Udaka, F., Oda, M., Tamura, A., Kubori, T., Nishinaka, K. and Kameyama, M. Parkinsons disease following panic disorder.J Neuropsychiatry Clin Neurosci18(1): 130, 2006.

Matsui, H.*, Udaka, F., Tamura, A., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. Impaired visual acuity as a risk factor for visual hallucinations in Parkinsons disease.J Geriatr Psychiatry Neurol19(1): 36-40, 2006.

2005年
Matsui, H.*, Udaka, F., Tamura, A., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. Multiple sclerosis following splenectomy as a treatment for idiopathic thrombocytopenic purpura.Intern Med44(7): 747-749, 2005.

Matsui, H.*, Udaka, F., Tamura, A., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. The relation between visual hallucinations and visual evoked potential in Parkinson disease.Clin Neuropharmacol28(2): 79-82, 2005.

Matsui, H.*, Udaka, F., Kubori, T., Oda, M., Nishinaka, K. and Kameyama, M. Persistent primitive hypoglossal artery with atrial septal defect.Intern Med44(5): 507-508, 2005.

Matsui, H.*, Udaka, F., Miyoshi, T., Hara, N., Tamaura, A., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinsons disease.Mov Disord20(10): 1272-1277, 2005.

Matsui, H.*, Udaka, F., Miyoshi, T., Hara, N., Tamura, A., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. N-isopropyl-p- 123I iodoamphetamine single photon emission computed tomography study of Parkinsons disease with dementia.Intern Med44(10): 1046-1050, 2005.

Matsui, H.*, Udaka, F., Miyoshi, T., Hara, N., Tamura, A., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. Brain perfusion differences between Parkinsons disease and multiple system atrophy with predominant parkinsonian features.Parkinsonism Relat Disord11(4): 227-232, 2005.

Matsui, H.*, Udaka, F., Oda, M., Kubori, T., Nishinaka, K. and Kameyama, M. Metaiodobenzylguanidine (MIBG) scintigraphy at various parts of the body in Parkinsons disease and multiple system atrophy.Auton Neurosci119(1): 56-60, 2005.

Matsui, H.*, Udaka, F., Oda, M., Tamura, A., Kubori, T., Nishinaka, K. and Kameyama, M. Metaiodobenzylguanidine (MIBG) uptake in Parkinsons disease also decreases at thyroid.Ann Nucl Med19(3): 225-229, 2005.

2004年
Matsui, H.*, Udaka, F., Kubori, T., Oda, M., Nishinaka, K. and Kameyama, M. POEMS syndrome demonstrating VEGF decrease by ticlopidine.Intern Med43(11): 1082-1083, 2004.

論文（総説）および著書
松井秀彰*. 動物の多様な脳をモデルとした疾患研究. Clinical Neuroscience 41(12): 1611-1615, 2023

松井秀彰*. 異所性核酸. 生化学, 94(6): 929, 2022

松井秀彰*. ミトコンドリアDNAの漏出が引き起こす細胞死. 生化学 94(5): 696-700, 2022

松井秀彰*. 小型魚類で明らかにする生老病死. 新潟医学会雑誌 135(8): 143-148, 2021

松井秀彰*. 細胞質に漏出したmtDNAが惹起するパーキンソン病の神経変性. 実験医学 39(16), 2021
https://www.yodosha.co.jp/jikkenigaku/book/9784758125482/index.html

松井秀彰*. 小型魚類を用いた医学研究. 新潟県医師会報 10(847): 2-6, 2020

松井秀彰*. パーキンソン病という病気 その１. 脳研究所コラム, 2018 (3/1open)

松井秀彰*. αシヌクレインとそのリン酸化. Medical Science Digest 44(3): 66-67, 2018

松井秀彰*.　パーキンソン病はリソソーム異常が原因である:「Yes」の立場から. Frontiers in Parkinson Disease 11(2): 78-81, 2018.

松井秀彰*. 興奮毒性. 日本臨床パーキンソン病（第2版）—基礎・臨床研究のアップデート— 162-166, 2018 (5/31発行)

松井秀彰*. アフリカメダカは老化とともにパーキンソン病に罹患する. 新潟医学会雑誌132(5): 166-180, 2018

松井秀彰*. 小型魚類を利用したパーキンソン病モデル. 別冊・医学のあゆみ パーキンソン病の新展開—発症の分子機構と新規治療 53-58, 2018 (6/20発行)

松井秀彰*. 小型魚類を利用したパーキンソン病モデル. 医学のあゆみJournal of Clinical and Experimental Medicine 262(6): 635-640, 2017 (8/5発行)

松井秀彰*. 小型魚類を用いた神経精神疾患研究. ブレインサイエンス•レビュー2017 253-270, 2017 (2/15発行)

松井秀彰*. 生命科学を開く新しい実験動物モデル-11. 超短命脊椎動物アフリカメダカ. 生体の科学SEITAI NO KAGAKU 68(1): 80-84, 2017 (2/15発行)

髙橋良輔、永井義隆、松井秀彰、佐藤栄人、望月秀樹. 座談会 パーキンソン病の動物モデル―最近の話題. Frontiers in Parkinson's Disease 9(1): 5-13, 2016.

松井秀彰、高橋良輔. パーキンソン病の小型魚類モデル. BIO Clinica 30(9): 757-760, 2015.

松井秀彰、高橋良輔. パーキンソン病の発症機構. Brain and Nerve: 神経研究の進歩 61(4): 441-446, 2009.

松井秀彰、高橋良輔. キーワード　蛋白質の一生：パーキンソン病. 蛋白質核酸酵素 53(8): 981, 2008.

松井秀彰、高橋良輔. パーキンソン病関連遺伝子：PINK1、DJ-1、LRRK2. 実験医学 25(13): 1969-1973, 2007.