Structural and metabolic signatures of cardiac aging in African turquoise killifish (Nothobranchius furzeri) Histol. Histopathol. , 2026.
業績
2026
原著論文
A protective role for APP in nuclear waste clearance via lysosomal exocytosis Proc. Natl. Acad. Sci. USA 123(24) : e2524190123 , 2026.
↳ 本論文を紹介するPNAS Commentary: Thangavel, M., Masurkar, A. V. Nuclear garbage disposal: An unexpected role for amyloid precursor protein in Alzheimer’s disease. Proc. Natl. Acad. Sci. USA, 2026. doi:10.1073/pnas.2619791123
A cost-effective method to assess light/dark preference and activity in zebrafish larvae Heliyon 12(4) : e44675 , 2026.
Crosstalk between ApoE-expressing cells and genotoxic stress in the mouse brain Brain Res. 1871 : 150080 , 2026.
総説
Loss of tissue-state plasticity: a conceptual framework for age-associated regenerative failure Inflamm. Regener. , 2026.
2025
原著論文
Behavioral and molecular insights into anxiety in ube3a and fmr1 zebrafish models of autism spectrum disorders Transl. Psychiatry 15(1) : 512 , 2025.
Mutation of ube3a causes developmental abnormalities and autism-like molecular and behavioral alterations in zebrafish Brain Res. Bull. 231 : 111542 , 2025.
A robust protocol for proteomic profiling of secreted proteins in conditioned culture medium Biol. Methods Protoc. 10(1) : bpaf068 , 2025.
Lipofuscin autofluorescence confounds intracellular amyloid β detection in the aged mouse brain Aging Brain 8 : 100148 , 2025.
Environmental context modulates sociability in ube3a zebrafish mutants via alterations in sensory pathways Mol. Psychiatry 31(1) : 158-172 , 2025.
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs Mech. Ageing Dev. 226 : 112087 , 2025.
Phosphorylation of optineurin by TBK1 drives fragmentation of Golgi apparatus Biochem. Biophys. Res. Commun. 752 : 151447 , 2025.
総説
Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease Transl. Neurodegener. 14(1) : 67 , 2025.
Exploring α-Syn’s Functions Through Ablation Models: Physiological and Pathological Implications Cell. Mol. Neurobiol. 45(1) : 44 , 2025.
Three decades of neuroscience research using animal models of ADHD and ASD: a bibliometric analysis Front. Psychiatry 16 : 1528205 , 2025.
2024
原著論文
Homozygous slc25a20 zebrafish mutant reveals insights into carnitine-acylcarnitine translocase deficiency pathogenesis Mol. Genet. Metab. Rep. 41 : 101165 , 2024.
Single housing of juveniles accelerates early-stage growth but extends adult lifespan in African turquoise killifish Aging 16(18) : 12443-12472 , 2024.
Current trends in basic research on Parkinson's disease: from mitochondria, lysosome to α-synuclein J. Neural Transm. 131(6) : 663-674 , 2024.
The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development J. Biol. Chem. 300(2) : 105629 , 2024.
GPATCH4 contributes to nucleolus morphology and its dysfunction impairs cell viability Biochem. Biophys. Res. Commun. 693 : 149384 , 2024.
総説
Modeling familial and sporadic Parkinson's disease in small fishes Dev. Growth Differ. 66(1) : 4-20 , 2024.
日本語総説
神経変性疾患と細胞老化 [Neurodegeneration and cellular senescence] 実験医学増刊「細胞老化―真の機能を深く理解する」 42(20) : 197-203 , 2024.
2023
原著論文
Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease Proc. Natl. Acad. Sci. USA 120(23) : e2214652120 , 2023.
Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner Front. Mol. Neurosci. 16 : 1166900 , 2023.
総説
Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders Int. J. Mol. Sci. 24(8) : 7079 , 2023.
日本語総説
動物の多様な脳をモデルとした疾患研究 [Disease research using diverse animal brains as models] Clinical Neuroscience 41(12) : 1611-1615 , 2023.
2022
原著論文
Glutamatergic pathways in the brains of turtles: A comparative perspective among reptiles, birds, and mammals Front. Neuroanat. 16 : 937504 , 2022.
The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders Front. Genet. 13 : 928597 , 2022.
Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish Int. J. Mol. Sci. 23(14) : 7550 , 2022.
Rapid reverse genetics systems for Nothobranchius furzeri, a suitable model organism to study vertebrate aging Sci. Rep. 12 : 11628 , 2022.
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration NeuroReport 33(7) : 320-325 , 2022.
Evaluation of Ectopic Mitochondrial DNA in HeLa Cells Curr. Issues Mol. Biol. 44(3) : 1215-1223 , 2022.
Zebrafish, Medaka and Turquoise Killifish for Understanding Human Neurodegenerative/Neurodevelopmental Disorders Int. J. Mol. Sci. 23(3) : 1399 , 2022.
Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson's disease Neural Regen. Res. 17(12) : 2682 , 2022.
日本語総説
異所性核酸 [Ectopic nucleic acids] 生化学 94(6) : 929 , 2022.
ミトコンドリアDNAの漏出が引き起こす細胞死 [Cell death caused by leakage of mitochondrial DNA] 生化学 94(5) : 696-700 , 2022.
2021
原著論文
Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease Nat. Commun. 12(1) : 3101 , 2021.
Esophageal High-Resolution Manometry for Diagnosing the Severity of the Chronic Intestinal Pseudo-Obstruction: A Case Series Dig. Dis. Sci. 66(11) : 3960-3967 , 2021.
日本語総説
小型魚類で明らかにする生老病死 [Life, aging, disease and death as seen in small fishes] 新潟医学会雑誌 135(8) : 143-148 , 2021.
細胞質に漏出したmtDNAが惹起するパーキンソン病の神経変性 [Parkinson's neurodegeneration driven by cytosolic mtDNA] 実験医学 39(16) , 2021.
2020
原著論文
Degeneration of dopaminergic neurons and impaired intracellular trafficking in Atp13a2 deficient zebrafish IBRO Rep. 9 : 1-8 , 2020.
日本語総説
小型魚類を用いた医学研究 [Medical research using small fishes] 新潟県医師会報 10(847) : 2-6 , 2020.
2019
原著論文
Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy Auton. Neurosci. 221 : 102583 , 2019.
Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri Cell Rep. 26(7) : 1727-1733.e6 , 2019.
2018
原著論文
Parkinson's disease pathogenesis from the viewpoint of small fish models J. Neural Transm. 125(1) : 25-33 , 2018.
日本語総説
パーキンソン病という病気 その1 [Parkinson's disease, part 1] 脳研究所コラム , 2018.
αシヌクレインとそのリン酸化 [α-Synuclein and its phosphorylation] Medical Science Digest 44(3) : 66-67 , 2018.
パーキンソン病はリソソーム異常が原因である:「Yes」の立場から [Parkinson's disease is caused by lysosomal dysfunction: the 'Yes' position] Frontiers in Parkinson Disease 11(2) : 78-81 , 2018.
アフリカメダカは老化とともにパーキンソン病に罹患する [The African killifish develops Parkinson's disease with aging] 新潟医学会雑誌 132(5) : 166-180 , 2018.
著書・分担執筆
興奮毒性 [Excitotoxicity] 日本臨床 パーキンソン病(第2版)—基礎・臨床研究のアップデート— : 162-166 , 2018.
小型魚類を利用したパーキンソン病モデル [Small-fish models of Parkinson's disease] 別冊・医学のあゆみ パーキンソン病の新展開—発症の分子機構と新規治療 : 53-58 , 2018.
2017
原著論文
Cerebrospinal fluid injection into adult zebrafish for disease research J. Neural Transm. 124(12) : 1627-1633 , 2017.
An optimized method for counting dopaminergic neurons in zebrafish PLoS One 12(9) : e0184363 , 2017.
Dopamine system, cerebellum, and nucleus ruber in fish and mammals Dev. Growth Differ. 59(4) : 219-227 , 2017.
The use of fish models to study human neurological disorders Neurosci. Res. 120 : 1-7 , 2017.
Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light J. Vis. Exp. , 2017.
日本語総説
小型魚類を利用したパーキンソン病モデル [Small-fish models of Parkinson's disease] 医学のあゆみ 262(6) : 635-640 , 2017.
生命科学を開く新しい実験動物モデル-11. 超短命脊椎動物アフリカメダカ [A new experimental animal for life science, 11: the extremely short-lived vertebrate Nothobranchius furzeri] 生体の科学 68(1) : 80-84 , 2017.
著書・分担執筆
小型魚類を用いた神経精神疾患研究 [Neuropsychiatric disease research in small fishes] ブレインサイエンス・レビュー2017 : 253-270 , 2017.
2016
その他
座談会 パーキンソン病の動物モデル―最近の話題 [Discussion: animal models of Parkinson's disease] Frontiers in Parkinson's Disease 9(1) : 5-13 , 2016.
2015
原著論文
Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles Dev. Dyn. 244(12) : 1574-1580 , 2015.
Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein PLoS Genet. 11(4) : e1005065 , 2015.
日本語総説
パーキンソン病の小型魚類モデル [Small-fish models of Parkinson's disease] BIO Clinica 30(9) : 757-760 , 2015.
2014
原著論文
Identification of the zebrafish red nucleus using Wheat Germ Agglutinin transneuronal tracing Commun. Integr. Biol. 7(6) : e994383 , 2014.
Functional regionalization of the teleost cerebellum analyzed in vivo Proc. Natl. Acad. Sci. USA 111(32) : 11846-11851 , 2014.
↳ 本論文を紹介するPNAS Commentary: Okamoto, H. Minicerebellum, now available for reductionists’ functional study. Proc. Natl. Acad. Sci. USA, 2014. doi:10.1073/pnas.1411821111
Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish Journal of Parkinson's Disease 4(2) : 301-310 , 2014.
2013
原著論文
ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons FEBS Lett. 587(9) : 1316-1325 , 2013.
PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates Hum. Mol. Genet. 22(12) : 2423-2434 , 2013.
TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency Ann. Neurol. 74(6) : 837-847 , 2013.
2012
原著論文
Medaka Fish Parkinson's Disease Model Exp. Neurobiol. 21(3) : 94-100 , 2012.
2010
原著論文
Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish J. Neurochem. 115(5) : 1150-1160 , 2010.
Proteasome inhibition in medaka brain induces the features of Parkinson's disease J. Neurochem. 115(1) : 178-187 , 2010.
Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement Neurosci. Res. 66(2) : 151-161 , 2010.
2009
原著論文
A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish Neurosci. Res. 65(3) : 263-271 , 2009.
日本語総説
パーキンソン病の発症機構 [Pathogenesis of Parkinson's disease] Brain and Nerve 61(4) : 441-446 , 2009.
2008
日本語総説
キーワード 蛋白質の一生:パーキンソン病 [Keyword: the life of proteins — Parkinson's disease] 蛋白質核酸酵素 53(8) : 981 , 2008.
2007
原著論文
Thalamic Hyperperfusion in Verbal Hallucination of Parkinsonian Patients Intern. Med. 46(21) : 1765-1769 , 2007.
Auditory event-related potentials in Parkinson's disease: Prominent correlation with attention Parkinsonism Relat. Disord. 13(7) : 394-398 , 2007.
Heterogeneous factors in dementia with Parkinson's disease: IMP-SPECT study Parkinsonism Relat. Disord. 13(3) : 174-181 , 2007.
Depression in Parkinson's disease J. Neurol. 254(9) : 1170-1173 , 2007.
Trousseau Syndrome Due to Pleural Mesothelioma Neurologist 13(4) : 205-208 , 2007.
Dementia in Parkinson's disease: diffusion tensor imaging Acta Neurol. Scand. 116(3) : 177-181 , 2007.
日本語総説
パーキンソン病関連遺伝子:PINK1、DJ-1、LRRK2 [Parkinson's disease genes: PINK1, DJ-1, LRRK2] 実験医学 25(13) : 1969-1973 , 2007.
2006
原著論文
Adult onset hemiparkinsonism with brain hemihypoplasia Neurol. India 54(4) : 450 , 2006.
Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations Mov. Disord. 21(12) : 2140-2144 , 2006.
Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations Mov. Disord. 21(12) : 2165-2169 , 2006.
Excessive Daytime Sleepiness in Parkinson Disease: A SPECT Study Sleep 29(7) : 917-920 , 2006.
Wisconsin Card Sorting Test and brain perfusion imaging in Parkinson's disease Parkinsonism Relat. Disord. 12(5) : 273-278 , 2006.
Minor depression and brain perfusion images in Parkinson's disease Mov. Disord. 21(8) : 1169-1174 , 2006.
Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease correlate with major autonomic symptoms? Parkinsonism Relat. Disord. 12(5) : 284-288 , 2006.
Disruptions of the fornix fiber in parkinsonian patients with excessive daytime sleepiness Parkinsonism Relat. Disord. 12(5) : 319-322 , 2006.
HTLV-I-Associated Peripheral Neuropathy With Smoldering-Type Adult T-Cell Leukemia Neurologist 12(2) : 109-113 , 2006.
Frontal Assessment Battery and Brain Perfusion Image in Parkinson's Disease J. Geriatr. Psychiatry Neurol. 19(1) : 41-45 , 2006.
Encephalopathy and severe neuropathy due to probable systemic vasculitis as an initial manifestation of mixed connective tissue disease Neurol. India 54(1) : 83 , 2006.
Parkinson's Disease Following Panic Disorder The Journal of Neuropsychiatry and Clinical Neurosciences 18(1) : 130-130 , 2006.
Impaired Visual Acuity as a Risk Factor for Visual Hallucinations in Parkinson's Disease J. Geriatr. Psychiatry Neurol. 19(1) : 36-40 , 2006.
2005
原著論文
Multiple Sclerosis Following Splenectomy as a Treatment for Idiopathic Thrombocytopenic Purpura Intern. Med. 44(7) : 747-749 , 2005.
The Relation Between Visual Hallucinations and Visual Evoked Potential in Parkinson Disease Clin. Neuropharmacol. 28(2) : 79-82 , 2005.
Persistent Primitive Hypoglossal Artery with Atrial Septal Defect Intern. Med. 44(5) : 507-508 , 2005.
Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease Mov. Disord. 20(10) : 1272-1277 , 2005.
N-isopropyl-p-123I Iodoamphetamine Single Photon Emission Computed Tomography Study of Parkinson's Disease with Dementia Intern. Med. 44(10) : 1046-1050 , 2005.
Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian features Parkinsonism Relat. Disord. 11(4) : 227-232 , 2005.
Metaiodobenzylguanidine (MIBG) scintigraphy at various parts of the body in Parkinson's disease and multiple system atrophy Auton. Neurosci. 119(1) : 56-60 , 2005.
Metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease also decreases at thyroid Ann. Nucl. Med. 19(3) : 225-229 , 2005.
2004
原著論文
POEMS Syndrome Demonstrating VEGF Decrease by Ticlopidine Intern. Med. 43(11) : 1082-1083 , 2004.