Brain Research Institute, Niigata University Field for Evolutionary Brain Pathology Department of Neuroscience of Disease Care fish, Cure human
Professor Hideaki Matsui

Hideaki Matsui

Professor; Director, Brain Research Institute

Career

Born July 1975, Osaka Prefecture, Japan March 2001: Graduated from Kyoto University, Faculty of Medicine May 2001: Medical license; resident in Internal Medicine, Kyoto University Hospital June 2002: Internal Medicine and General Practice, Sumitomo Hospital; later neurologist (Board Certified in Internal Medicine, September 2004) April 2006: Enrolled in the Graduate School of Medicine, Kyoto University, Department of Neurology March 2010: Ph.D. (Medicine), Kyoto University, Department of Neurology (Prof. Ryosuke Takahashi) January 2011: Postdoctoral Fellow, TU Braunschweig, Zoological Institute, Dept. Cell-Physiology (Humboldt Foundation Fellowship) (Prof. Reinhard Köster) January 2013: Postdoctoral Researcher, University of Miyazaki, Department of Integrated Physiology January 2014: Assistant Professor, University of Miyazaki, Department of Integrated Physiology January 2016: Tenure-Track Associate Professor (PI), Department of Neuroscience of Disease, Niigata University April 2020: Professor, Department of Neuroscience of Disease, Brain Research Institute, Niigata University February 2024: Deputy Director, Brain Research Institute, Niigata University February 2026: Director, Brain Research Institute, Niigata University

In their words

Since childhood, I have been fascinated by natural sciences and aspired to be a scientist like Einstein or Fleming. I entered medicine to learn about the human body and disease, and eventually chose neurology, a field with many intractable diseases. I am now a researcher, but I spent a long time in serious clinical practice (5 years full-time, 4.5 years part-time). The patients and others I met there remain a second motivation. A third is to deepen both scientific and social understanding of developmental disorders in children.

Selected publications

  • Dougnon, G., Otsuka, T., Nakamura, Y., Sakai, A., Yamanaka, T., Matsui, N., Nakahara, A., Ito, A., Hatano, A., Matsumoto, M., Igarashi, H., Kakita, A., Ueno, M., Matsui, H.*. A protective role for APP in nuclear waste clearance via lysosomal exocytosis. Proc. Natl. Acad. Sci. USA. 123(24):e2524190123. 2026. https://doi.org/10.1073/pnas.2524190123
  • Matsui, H.*, Ito, J., Matsui, N., Uechi, T., Onodera, O., Kakita, A. Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nat. Commun. 12(1):3101. 2021. https://doi.org/10.1038/s41467-021-23452-x
  • Matsui, H.*, Kenmochi, N., Namikawa, K. Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri. Cell Rep. 26(7):1727-1733.e6. 2019. https://doi.org/10.1016/j.celrep.2019.01.015