Pathological Neuroscience Branch
Department of Pathology


To provide the highest quality pathology services and scientific evidence focused on the advancement of developments in the field of neuropathology.


As an academic pathology department, we aim to deliver a high degree of professionalism in clinicopathological diagnostic services and neuropathology research, utilizing comprehensive and innovative approaches and building departmental competence to meet the needs of patients, institutions, and society.

Our approach will involve taking full advantage of opportunities to advance both the science and practice of neuropathology through individual and collaborative research, which hopefully will produce leading practitioners and researchers.

Prof. Akiyoshi KAKITA
Assoc. Prof. Hiroshi SHIMIZU
Specially Appointed Assoc. Prof. Hiroki KITAURA


Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids (HDLS). Iba1 immunohistochemistry revealed that microglia showed a relatively uniform and characteristically delicate morphology with narrow cytoplasm and thin, winding processes accompanying many knot-like structures (a, b). Ultrastructurally, the rough endoplasmic reticulum showed vesiculation and the polyribosomes were disaggregated in the microglial cytoplasm and processes, indicating of depressed protein synthesis (c). These morphological alterations of microglia seem to be associated with the pathogenesis of HDLS, and suggest that HDLS is a primary microglial disorder.

Related Sites

  • Niigata University Graduate School of Medical and Dental Sciences
  • School of Medicine, Faculty of Medicine, Niigata University
  • Niigata University