研究業績

Iida T., Igarashi A., Fukunaga K., Aoki T., Hidai T., Yanagi K., Yamamori M., Satou K., Go H., Kosho T., Maki R., Suzuki T., Nitta Y., Sugie A., Asaoka Y., Furutani-Seiki M., Kimura T., Matsubara Y., Kaname T. (2024) Functional analysis of RRAS2 pathogenic variants with a Noonan-like phenotype.

Osaka J, Ishii A, Wang X, Iwanaga R, Kawamura H, Akino S, Sugie A, Hakeda-Suzuki S, Suzuki T. (2024) Cell Rep. Feb 19;43(2):113798. doi: 10.1016/j.celrep.2024.113798. Online ahead of print. PMID: 38381608  Complex formation of immunoglobulin superfamily molecules Side-IV and Beat-IIb regulates synaptic specificity.

Vetro et al., (2023) The American Journal of Human Genetics Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration.

Yamada M., Nitta Y. Uehara T., Suzuki H., Takenouchi T., Tamura M., Ayabe S., Yoshiki A., Maeno A., Saga Y., Tamio Furuse T., Yamada I., Okamoto N., Sugie A.†, Kosaki K.†, (2023) European Journal of Medical Genetics Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders. † Co-corresponding authors

Nitta Y., Osaka J., Maki R., Hakeda-Suzuki S., Suzuki E., Ueki S., Suzuki T., Sugie A., (2023) eLife Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy. reviewed preprint

Itai T., Sugie A., Nitta Y., Maki R., Suzuki T., Shinkai Y., Watanabe Y., Nakano Y., Ichikawa K., Okamoto N., Utsuno Y., Koshimizu E., Fujita A., Hamanaka K., Uchiyama Y., Tsuchida N., Miyake N., Misawa K., Mizuguchi T., Miyatake S., Matsumoto N. (2023) Scientific Reports, Volume 13, Article number: 975. A novel NONO variant that causes developmental delay and cardiac phenotypes.

Nitta Y., Kawai H., Maki R., Osaka J., Hakeda-Suzuki S., Nagai Y., Doubková K., Uehara T., Watanabe K., Kosaki K., Suzuki T., Tavosanis G., Sugie A. (2023) Human Molecular Genetics, Volume 32, Issue 9, Pages 1524-1528. Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in Drosophila using the automated axon quantification system, MeDUsA. SugieLab/MeDUsA (github.com)

Osaka J., Yasuda H., Watanuki Y., Kato Y., Nitta Y., Sugie A., Sato M., Suzuki T. (2022) Genes & Genetic Systems, Volume 97, Issue 6, Pages 297-309. Identification of genes regulating stimulus-dependent synaptic assembly in Drosophila using an automated synapse quantification system.

Nitta Y., Sugie A.. (2022) Fly, Volume 16, Issue 1, Pages 275-298. Studies of neurodegenerative diseases using Drosophila and the development of novel approaches for their analysis.

Richard M., Doubková K., Nitta Y., Kawai H., Sugie A.†, Tavosanis G.† (2022) The Journal of Neuroscience, Volume 42, Issue 24, Pages 4937-4952. A Quantitative Model of Sporadic Axonal Degeneration in the Drosophila Visual System.† Co-corresponding authors

Utomo Y. R., Sugie A.†, Okada S., Miura K., Nakamura H.† (2022) Chemical Communications, Volume 58, Issue 15, Pages 2576-2579. Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer’s model. † Co-corresponding authors

Kato T., Manabe R., Igarashi H., Kametani F., Hirokawa S., Sekine Y., Fujita N., Saito S., Kawashima Y., Hatano Y., Ando S., Nozaki H., Sugai A., Uemura M., Fukunaga M., Sato T., Koyama A., Saito R., Sugie A., Toyoshima Y., Kawata H., Murayama S., Matsumoto M., Kakita A., Hasegawa M., Ihara M., Kanazawa M., Nishizawa M., Tsuji S., Onodera O. (2021) Journal of Clinical Investigation, Volume 131, Issue 22, e140555. Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model.

Sakamoto M., Sasaki K., Sugie A., Nitta Y., Kimura T., Gürsoy S., Cinleti T., Iai M., Sengoku T., Ogata K., Suzuki A, Okamoto N., Iwama K., Tsuchida N., Uchiyama Y., Koshimizu E., Fujita A., Hamanaka K., Miyatake S., Mizuguchi T., Taguri M., Ito S., Takahashi H., Miyake N., Matsumoto N. (2021) Human Molecular Genetics, Volume 31, Issue 1, Pages 69-81. De novo ARF3 variants cause neurodevelopmental disorder with brain abnormality

Takechi H., Hakeda-Suzuki S., Nitta Y., Ishiwata Y., Iwanaga R., Sato M., Sugie A., Suzuki T. (2021) eLife, Volume 10, e66718. Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance.

Nitta Y., Matsui S., Kato Y., Kaga Y., Sugimoto K., Sugie A. (2019) Scientific Reports, Volume 9, Article number: 8857. Analysing the evolutional and functional differentiation of four types of Daphnia magna cryptochrome in Drosophila circadian clock.

Sugie A., Marchetti G., Tavosanis G. (2018) Neural Development, Volume 13, Article number: 14. Structural aspects of plasticity in the nervous system of Drosophila.

Sugie A.†, Möhl C.†, Hakeda-Suzuki S., Matsui H., Suzuki T., Tavosanis G. (2017) Journal of Visualized Experiments, 120, e55716. Analyzing synaptic modulation of Drosophila photoreceptors after exposure to prolonged light. † Co-corresponding authors

Nitta Y.† and Sugie A.† (2017) Biochemical and Biophysical Research Communications, Volume 487, Issue 1, Pages 116-121. DISCO Interacting Protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body.  † Co-corresponding authors

Nitta Y.† and Sugie A.† (2017) Biochemical and Biophysical Research Communications, Volume 487, Issue 4, Pages 898-902. Identification of glaikit in a genome-wide expression profiling for axonal bifurcation of the mushroom body in Drosophila.   † Co-corresponding authors

Nitta Y., Yamazaki D., Sugie A., Hiroi M., Tabata T. (2017) Developmental Biology, Volume 421, Issue 2, Pages 233-244. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons.

Sugie A., Hakeda-Suzuki S., Suzuki E., Silies M., Shimozono M., Möhl C., Suzuki T. and Tavosanis G. (2015) Neuron, Volume 86, Issue 3, Pages 711-725. Molecular remodeling of the presynaptic active zone of Drosophila photoreceptors via activity-dependent feedback.

Berger-Müller S.†, Sugie A.†, Takahashi F., Tavosanis G., Hakeda-Suzuki S., Suzuki T. (2013) PLOS ONE, Volume 8, Issue 12, e83732. Assessing the role of cell-surface molecules in central synaptogenesis in the Drosophila visual system.
†These authors contributed equally.

Sugie A., Umetsu D., Yasugi T., Fischbach K-F., Tabata T. (2010) Development, Volume 137, Issue 19, Pages 3303-3313. Recognition of pre- and postsynaptic neurons via nephrin/NEPH1 homologs is a basis for the formation of the Drosophila retinotopic map.

Yasugi T., Sugie A., Umetsu D., Tabata T. (2010) Development, Volume 137, Issue 19, Pages 3193-3203. Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe.

Taniue K., Nishida A., Hamada F., Sugie A., Oda T., Ui-Tei K., Tabata T., Akiyama T. (2010) Development, Volume 137, Issue 10, Pages 1755-1764. Sunspot, a link between Wingless signaling and endoreplication in Drosophila.

Mizuno N., Sugie A., Kobayashi F., Takumi S. (2008) Journal of Plant Physiology, Urban & Fischer, Volume 165, Issue 4, Pages 462-467. Mitochondrial alternative pathway is associated with development of freezing tolerance in common wheat.

Sugie A., Murai K., Takumi S. (2007) Genes and Genetic Systems, Genetics Society Of Japan, Volume 82, Issue 3, Pages 231-239. Alteration of respiration capacity and transcript accumulation level of alternative oxidase genes in necrosis lines of common wheat.

Sugie A., Naydenov N., Mizuno N., Nakamura C., Takumi S. (2006) Genes and Genetic Systems, Genetics Society Of Japan, Volume 81, Issue 5, Pages 349-354. Overexpression of wheat alternative oxidase gene Waox1a alters respiration capacity and response to reactive oxygen species under low temperature in transgenic Arabidopsis.