• Mikuni T, Uchigashima M. Methodological approaches to understand the molecular mechanism of structural plasticity of dendritic spines.

Eur J Neurosci. in press.
 

• Mikuni T. Genome editing-based approaches for imaging protein localization and dynamics in the mammalian brain.

Neurosci Res. 2020;150:2-7.
 

1. Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao T, Mikuni T, Watanabe M, Sakimura K, Kano M. Retrograde signaling from Progranulin to Sort1 counteracts synapse elimination in the developing cerebellum.

Neuron. 2018; 97(4):796–805.
 

1. Nishiyama J*, Mikuni T*†, Yasuda R†. Virus-mediated genome editing via homology-directed repair in mitotic and postmitotic cells in mammalian brain.

Neuron. 2017; 96(4):755-68.
    *Co-first authors
    †Corresponding authors
     - Featured in Nat Rev Neurosci
 

1. Aikawa T, Watanabe T, Miyazaki T, Mikuni T, Wakamori M, Sakurai M, Aizawa H, Ishizu N, Watanabe M, Kano M, Mizusawa H, Watase K. Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice.

Hum Mol Genet. 2017; 26(16):3094-104.
 

1. Mikuni T*, Nishiyama J*, Sun Y, Kamasawa N, Yasuda R. High-throughput, high-resolution mapping of protein localization in mammalian brain by in vivo genome editing.

Cell. 2016; 165(7):1803-17.
     - Selected as “Best of Cell 2016” paper
     - Featured in Nat Rev Neurosci
 

1. Kamasawa N, Sun Y, Mikuni T, Guerrero-Given D, Yasuda R. Correlative ultrastructural analysis of functionally modulated synapses using automatic tape-collecting ultramicrotome – SEM array tomography.

Microsc and Microanal. 2015; 21, Supple S3, 1271-2.
 

1. Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M. Retrograde signaling for climbing fiber synapse elimination.

Cerebellum. 2015; 14(1):4-7.
 

1. Kawata S, Miyazaki T, Yamazaki M, Mikuni T, Yamasaki M, Hashimoto K, Watanabe M, Sakimura K, Kano M. Global scaling down of excitatory postsynaptic responses in cerebellar Purkinje cells impairs developmental synapse elimination.

Cell Rep. 2014; 8(4):1119-29.
 

1. Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M. Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.

Science. 2014; 344(6187):1020-3.
 

1. Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M. Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.

Neuron. 2013; 78(6):1024-35.
 

1. Uesaka N, Mikuni T, Hashimoto K, Hirai H, Sakimura K, Kano M. Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain.

J Neurosci. 2012; 32(34):11657-70.
 

1. Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Abe M, Hashimoto K, Watanabe M, Sakimura K, Kano M. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression.

Proc Nat Acad Sci USA. 2012; 109(30):12195-200.
 

1. Kimura N, Fujii T, Miyajima T, Kumada T, Mikuni T, Ito M. Initial and long-term effects of cloxazolam with intractable epilepsy.

Pediatr Neurol. 2010; 43(6):403-6.