■英文

[2009]

1. Kitamura N, Akazawa K, Miyashita A, Kuwano R, Toyabe SI, Nakamura J, Nakamura N, Sato T, Hoque MA. Programs for calculating the statistical powers of detecting susceptibility genes in case-control studies based on multistage designs. Bioinformatics. 25:272-273. (2009)
   
   
2. Takei N, Miyashita A, Tsukie T, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kimura H, Kakita A, Takahashi H, Tsuji S, Kanazawa I, Ihara Y, Odani S, Kuwano R, and the Japanese Genetic Study Consortium for Alzheimer Disease. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics. 93:441-448. (2009)
   
   
3. Kasuga K, Ohno T, Ishihara T, Miyashita A, Kuwano R, Onodera O, Nishizawa M, Ikeuchi T. Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation. J Neurol. 256:1351-1353. (2009)
   
   
4. Hara K, Shiga A, Fukutake T, Nozaki H, Miyashita A, Yokoseki A, Kawata H, Koyama A, Arima K, Takahashi T, Ikeda M, Shiota H, Tamura M, Shimoe Y, Hirayama M, Arisato T, Yanagawa S, Tanaka A, Nakano I, Ikeda S, Yoshida Y, Yamamoto T, Ikeuchi T, Kuwano R, Nishizawa M, Tsuji S, Onodera O. Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease. N Engl J Med. 360:1729-1739. (2009)
   
5. Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R. GAB2 is not associated with late-onset Alzheimer’s disease in Japanese. Eur J Hum Genet. 17:682-686. (2009)
   
   
6. Fukuda Y, Nakahara Y, Date H, Takahashi Y, Goto J, Miyashita A, Kuwano R, Adachi H, Nakamura E, Tsuji S. SNP HiTLink: a high-throughput linkage analysis system employing dense SNP data. BMC Bioinformatics. 10:121. (2009)
   
   
7. Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M. The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system. EMBO Mol Med. 1:1-13. (2009)
   
   
8. Kasuga K, Shimohata T, Nishimura A, Shiga A, Mizuguchi T, Tokunaga J, Ohno T, Miyashita A, Kuwano R, Matsumoto N, Onodera O, Nishizawa M, Ikeuchi T. Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer's disease. J Neurol Neurosurg Psychiatry. 80:1050-1052. (2009)
   
   
9. Hamaguchi T, Morinaga A, Tsukie T, Kuwano R, Yamada M. A novel presenilin 1 mutation (L282F) in familial Alzheimer's disease. J Neurol. 256:1575 -1577. (2009)
   

 

[2008]

1. Kitamura N, Akazawa K, Toyabe S, Miyashita A, Kuwano R, Nakamura J. Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes. J Hum Genet.53:390-400. (2008)
   
   
2. Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H, Takuma H, Kuwano R, Imagawa M, Ataka S, Wada Y, Yoshioka E, Nishizaki T, Watanabe Y, and Mori H. A new amyloid ss variant favoring oligomerization in Alzheimer-type dementia. Ann Neurol. 63:377-387. (2008)
   
   
3. Ikeuchi T, Kaneko H, Miyashita A, Nozaki H, Kasuga K, Tsukie T, Tsuchiya M, Imamura T, Ishizu H, Aoki K, Ishikawa A, Onodera O, Kuwano R, Nishizawa M. Mutational Analysis in Early-Onset Familial Dementia in Japanese Population: Role of PSEN1 and MAPT R406W Mutation. Dement Geriatr Cogn Disord. 26:43-49. (2008)
   
   
4. Abe TK, Honda T, Takei K, Mikoshiba K, Hoffman-Kim D, Jay DG, Kuwano R. Dynactin is essential for growth cone advance. Biochem Biophys Res Commun. 372:418-422. (2008)
   
   
5. Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M. Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controls. Brain Res. 1219C:169-179. (2008)
   
   
6. Yoshida S, Miyashita A, Kuwano R, Kojima T, Sasaki T, Gang Z, Kanai K, Fujita H, Hirose S, Kaneko S; Epilepsy Genetic Study Group. Genome-wide identification of febrile seizure and related epilepsy phenotype loci. Epilepsy Seizure. 1:30-39. (2008)
   
   
7. Toyabe S, Miyashita A, Kitamura N, Kuwano R, Akazawa K. Prediction of disease-associated single nucleotide polymorphisms using virtual genomes constructed from a public haplotype database. Methods Inf Med. 47:522-528. (2008)

[2007]

1. Shimohata T, Hara K, Sanpei K, Nunomura J, Maeda T, Kawachi I, Kanazawa M, Kasuga K, Miyashita A, Kuwano R, Hirota K, Tsuji S, Onodera O, Nishizawa M, Honma Y. Novel locus for benign hereditary chorea with adult-onset maps to chromosome 8q22.2-q23.3. Brain. 130:2302-2309. (2007)
   
   
2. Maksimova N, Hara K, Miyashita A, Nikolaeva I, Shiga A, Nogovicina A, Sukhomyasova A, Argunov V, Shvedova A, Ikeuchi T, Nishizawa M, Kuwano R, Osamu O. Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: New population isolate in Asia. J. Med. Genet. 44:772-778. (2007).
   
   
3. Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R; The Japanese Genetic Study Consortium for Alzeheimer's Disease. Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. Hum Mol Genet. 16:2854-2869. (2007)
   
   
4. Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T. Enhanced accumulation of phosphorylated a-synuclein and elevated Ab42/40 ratio caused by expression of the presenilin-1 delT440 mutant associated with familial Lewy Body disease and variant Alzheimer disease. J Neurosci. 27:13092-13097. (2007)

[2006]

1. Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Toyabe S, Akazawa K, Kanazawa I, Ihara Y; Japanese Genetic Study Consortium for Alzeheimer's Disease. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Hum Mol Genet. 15:2170-2182. (2006)
   
   
2. Kuramoto H, Kadowaki M, Yamamoto T, Kuwano R. Calbindin is predominantly expressed in nitrergic neurons in rat esophagus. Neurosci Lett. 401:174-177. (2006)
   
   
3. Nakazato T, Shingaki S, Kitamura N, Saito C, Kuwano R, Tachibana M. Expression level of vascular endothelial growth factor-C and -A in cultured human oral squamous cell carcinoma correlates respectively with lymphatic metastasis and angiogenesis when transplanted into nude mouse oral cavity. Oncol Rep. 15:825-830. (2006)

[2005]

1. Shoji M, Kuwano R, Asada T, Imagawa M, Higuchi S, Urakami K, Arai H, Ihara Y; Japanese Study Group Genome-wide screening for Genes associated Alzheimer's disease; Advanced Brain Science Project. [A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease] Rinsho Shinkeigaku. 45:128-137. (2005)
   
   
2. Ishikawa A, Piao YS, Miyashita A, Kuwano R, Onodera O, Ohtake H, Suzuki M.　Nishizawa M, Takahashi H. A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease. Ann Neurol. 57:429-434 (2005)

[2004]

1. Shimomura Y, Sato N, Miyashita A, Hashimoto T, Ito M, Kuwano R. A Rare Case of Hypohidrotic Ectodermal Dysplasia Caused by Compound Heterozygous Mutations in the EDAR Gene. J Invest Dermatol.123:649-655 (2004)
   
   
2. Hara K, Fukushima T.Suzuki T, Shimohata T, Oyake M, Ishiguro H, Hirota K, Miyashita A, Kuwano R, Kurisaki H, Yomono H, Goto J, Kanazawa I, Tsuji S. Japanese SCA families with a distinct phenotype linked to a locus overlapping with SCA15 locus. Neurology. 62, 648-651 (2004)
   
   
3. Gu W, Ogose A, Kawashima H, Ito M, Ito T, Matsuba A, Kitahara H, Hotta T, Tokunaga K, Hatano H, Morita T, Urakawa S, Yoshizawa T, Kawashima H, Kuwano R, Endo N. High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumors. Clin Cancer Res. 10:3831-3838. (2004)
   
   
4. Nasuno A, Toba K, Ozawa T, Hanawa H, Osman Y, Hotta Y, Yoshida K, Saigawa T, Kato K, Kuwano R, Watanabe K, Aizawa Y. Expression of coxsackievirus and adenovirus receptor in neointima of the rat carotid artery. Cardiovasc Pathol. 13:79-84. (2004)
   
   
5. Kashimura T, Kodama M, Hotta Y, Hosoya J, Yoshida K, Ozawa T, Watanabe R, Okura Y, Kato K, Hanawa H, Kuwano R, Aizawa Y. Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat. Virchows Arch. 444:283-292. (2004)

[2003]

1. Hotta Y, Honda T, Naito M, Kuwano R. Developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system. Brain Res Dev Brain Res. 143:1-13 (2003)
   
   
2. Ito T, Tokunaga K, Maruyama H, Kawashima H, Kitahara H, Horikoshi T, Ogose A, Hotta Y, Kuwano R, Katagiri H, Endo N. Coxsackievirus and adenovirus receptor (CAR)-positive immature osteoblasts as targets of adenovirus-mediated gene transfer for fracture healing. Gene Ther. 10:1623-1628. (2003)
   
   
3. Ishii N, Kuwano R, Watanabe YG. Possible involvement of Ankhzn, a novel protein possessing FYVE domain, in cellular endocytosis and autophagocytosis in vitro. Kaibogaku Zasshi. 78:53-58. (2003)
   
   
4. Nagai M, Yaoita E, Yoshida Y, Kuwano R, Nameta M, Ohshiro K, Isome M, Fujinaka H, Suzuki S, Suzuki J, Suzuki H, Yamamoto T. Coxsackievirus and adenovirus receptor, a tight junction membrane protein, is expressed in glomerular podocytes in the kidney. Lab Invest. 83:901-911. (2003)

 

 

■和文

[2009]

1. 桑野良三, 武井教展, 宮下哲典. 認知症. 日本臨床. 2009, 67:1078-1082.
   
   
2. 桑野良三, 宮下哲典. アルツハイマー病の遺伝素因. 実験医学（増刊）. 2009, 27(12):1848-1853.
   
   
3. 桑野良三. アルツハイマー病の大規模遺伝子解析. 新潟医学会誌. 2009, 123(7):325-332.
   
   
4. 桑野良三. 「誌上ディベート」ゲノム解析において今後どの手法がより重要な位置を占めるか？「ゲノムワイド関連解析が重要な位置を占めるとの立場から」. Cognition and Dementia. 2009, 8(4):318-321
   

[2008]

1. 月江珠緒, 宮下哲典, 桑野良三. 関連遺伝子の探索-候補遺伝子アプローチ-. 日本臨床. 2008, 66(増刊号1):164-168.
   
   
2. 宮下哲典, 桑野良三. アルツハイマー病の性差依存的なリスク遺伝子. 治療. 2008, 90(4): 1582-1585.
   
   
3. 宮下哲典, 桑野良三. 認知症の関連解析. Cognition and Dementia. 2008, 7(3):215-222
   
   
4. 桑野良三. 遺伝素因. 治療学. 2008, 42(6):639-642.

[2007]

1. 桑野良三. アルツハイマー病と遺伝子. 新潟医学会誌. 2007, 121(8):432-437.
   
   
2. 桑野良三．認知症「治療を展望したAlzheimer病の早期診断-MCIから初期Alzheimer病へ」リスクファクターとしての遺伝子. 臨床神経学. 2007, 47(11): 908-911.
   
   
3. 原賢寿, 桑野良三, 宮下哲典, 小久保康昌, 佐々木良元, 中原康雄, 後藤順, 西澤正豊, 葛原茂樹, 辻省次. 西太平洋地域の筋萎縮性側索硬化症/パーキンソン痴呆複合（ALS/PDC）と関連神経変性疾患・紀伊ALS/PDCの分子遺伝学的解析. 臨床神経学. 2007, 47(11): 974-976.

 

[2006]

1. 宮下哲典, 桑野良三. アルツハイマー病のリスク遺伝子. Pharma Medica. 2006, 24(7):13-17.
   
   
2. 桑野良三, 宮下哲典. Genetic riskとpatient selection. Cognition and Dementa. 2006, 5(4):307-315.
   
   
3. 桑野良三, 宮下哲典. リスク遺伝子（アポリポ蛋白E4）とアルツハイマー病. 老年期認知症ナビゲータ－（メディカルレビュー社）. 2006, 296-297.
   
   
4. 桑野良三, 宮下哲典. 遺伝子診断. アルツハイマー病診断-早期発見・早期介入のために-（真興交易医書出版部）. 2006, 127-138.

[2005]

1. 桑野良三. ゲノムスキャンによる日本人のAlzheimer病危険因子同定の試み. 医学のあゆみ. 2005, 212(10):925-929.
   
   
2. 桑野良三. アルツハイマー病：治療の可能性を探る. 2005 第19回「大学と科学」公開シンポジウム講演収録集. 124-135.
   
   
3. 東海林幹夫，桑野良三，朝田隆，今川正樹，樋口進，浦上克哉，荒井啓行，井原康夫. アルツハイマー病診断・評価基準試案 文部科学省特定領域研究「先端脳」ゲノム班．臨床神経学. 2005, 45(2):128-137.
   
   
4. 宮下哲典, 桑野良三. アルツハイマー病の分子遺伝学. 蛋白質核酸酵素. 2005, 50(16):2122-2127.
   
   
5. 宮下哲典, 桑野良三. 単一遺伝子病-アルツハイマー病. ゲノム医学. 2005, 5 (2005-4):197-203.

[2003]

1. 桑野良三, 宮下哲典. マイクロサテライト解析による病因遺伝子の網羅的探索. ゲノム医学. 2003, 3(2003-10): 523-528.