/* Academic editorial stylesheet — Department of Neuroscience of Disease */
:root {
  --ink: #1b1d1c;
  --ink-soft: #3a3c3a;
  --muted: #5e5c57;
  --paper: #f4f1ea;
  --panel: #fffcf7;
  --rule: #d7d1c4;
  --rule-strong: #b9b1a2;
  --accent: #6e1d28;
  --accent-hover: #4e121b;
  --link: #1e4a66;
  --link-hover: #0f2d40;
  --focus: #c45c26;
  --ok: #2b4a3e;
  --header-bg: #f7f4ee;
  --stage: #07131e;
  --stage-2: #0d2030;
  --stage-ink: #f4f1ea;
  --stage-muted: #c9c3b8;
  --shadow: 0 1px 0 var(--rule);
  --space-1: 0.25rem;
  --space-2: 0.5rem;
  --space-3: 0.75rem;
  --space-4: 1rem;
  --space-5: 1.5rem;
  --space-6: 2rem;
  --space-7: 3rem;
  --space-8: 4rem;
  --measure: 42rem;
  --page: 72rem;
  --font-serif: "Iowan Old Style", "Palatino Linotype", "Hiragino Mincho ProN", "Yu Mincho", "Noto Serif JP", serif;
  --font-sans: "Hiragino Sans", "Yu Gothic", "Noto Sans JP", "Segoe UI", sans-serif;
  --lh: 1.85;
  --radius: 2px;
}

*, *::before, *::after { box-sizing: border-box; }
html { scroll-behavior: smooth; }
@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  * { animation: none !important; transition: none !important; }
}

body {
  margin: 0;
  background: var(--paper);
  color: var(--ink);
  font-family: var(--font-sans);
  font-size: 1.05rem;
  line-height: var(--lh);
}

img { max-width: 100%; height: auto; display: block; }
a { color: var(--link); text-decoration-thickness: 1px; text-underline-offset: 0.18em; }
a:hover { color: var(--link-hover); }
a:focus-visible, button:focus-visible, summary:focus-visible {
  outline: 3px solid var(--focus);
  outline-offset: 3px;
}

.skip-link {
  position: absolute;
  left: var(--space-4);
  top: -100px;
  background: var(--ink);
  color: var(--panel);
  padding: var(--space-2) var(--space-4);
  z-index: 100;
}
.skip-link:focus { top: var(--space-2); }

.wrap {
  width: min(100% - 2.5rem, var(--page));
  margin-inline: auto;
}
.prose-measure { max-width: var(--measure); }

.site-header {
  background: var(--header-bg);
  border-bottom: 1px solid var(--rule);
}
.header-bar {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: var(--space-5);
  padding: var(--space-4) 0 var(--space-3);
  flex-wrap: wrap;
}
.brand {
  text-decoration: none;
  color: inherit;
  min-width: 0;
}
.brand-kicker {
  display: block;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  color: var(--muted);
  margin-bottom: 0.15rem;
}
.brand-field {
  display: block;
  margin-top: 0.1rem;
  font-size: 0.82rem;
  color: var(--ink-soft);
}
.brand-name {
  display: block;
  font-family: var(--font-serif);
  font-size: clamp(1.15rem, 2vw, 1.45rem);
  font-weight: 600;
  line-height: 1.3;
  color: var(--ink);
}
.brand-tag {
  display: block;
  margin-top: 0.2rem;
  font-style: italic;
  color: var(--accent);
  font-size: 0.95rem;
}

.header-tools {
  display: flex;
  align-items: center;
  gap: var(--space-4);
  flex-shrink: 0;
  margin-left: auto;
}
.lang-switch {
  font-size: 0.9rem;
  white-space: nowrap;
}
.lang-switch [aria-current="page"] {
  color: var(--ink);
  font-weight: 700;
  text-decoration: none;
}

.nav-toggle {
  display: none;
  background: transparent;
  border: 1px solid var(--rule-strong);
  color: var(--ink);
  padding: 0.4rem 0.7rem;
  font: inherit;
  cursor: pointer;
}
.nav-toggle:focus-visible {
  outline: 3px solid var(--focus);
  outline-offset: 3px;
}

.site-nav {
  border-top: 1px solid var(--rule);
}
.nav-list {
  display: flex;
  flex-wrap: wrap;
  gap: 0;
  list-style: none;
  margin: 0;
  padding: 0;
}
.nav-list > li > a {
  display: block;
  padding: 0.7rem 0.9rem 0.75rem;
  color: var(--ink-soft);
  text-decoration: none;
  border-bottom: 3px solid transparent;
  font-size: 0.95rem;
}
.nav-list > li > a:hover,
.nav-list > li > a[aria-current="page"] {
  color: var(--accent);
  border-bottom-color: var(--accent);
}
.has-sub { position: relative; }
.sub-nav {
  display: none;
  position: absolute;
  left: 0;
  top: 100%;
  background: var(--panel);
  border: 1px solid var(--rule);
  min-width: 14rem;
  z-index: 20;
  padding: 0.4rem 0;
  list-style: none;
  margin: 0;
  box-shadow: 0 8px 24px rgba(0,0,0,0.06);
}
.has-sub:hover > .sub-nav,
.has-sub:focus-within > .sub-nav { display: block; }
.sub-nav a {
  display: block;
  padding: 0.4rem 0.9rem;
  color: var(--ink);
  text-decoration: none;
}
.sub-nav a:hover { background: var(--paper); }

main {
  padding: var(--space-7) 0 var(--space-8);
  min-height: 60vh;
}

.hero {
  display: grid;
  grid-template-columns: minmax(0, 1.15fr) minmax(0, 0.85fr);
  gap: var(--space-6);
  align-items: center;
  margin-bottom: var(--space-7);
}
.hero h1 {
  font-family: var(--font-serif);
  font-size: clamp(1.7rem, 3.2vw, 2.35rem);
  line-height: 1.35;
  font-weight: 600;
  margin: 0 0 var(--space-4);
}
.lede {
  font-size: 1.08rem;
  color: var(--ink-soft);
  margin: 0 0 var(--space-5);
}
.hero-actions { display: flex; flex-wrap: wrap; gap: var(--space-3); }
.hero-tagline { font-family: var(--font-serif); font-size: 1.15rem; font-weight: 600; margin: 0 0 var(--space-4); }
.join-invite { border-top: 3px solid var(--accent); padding-top: var(--space-4); }
.story-brief-heading { margin-top: var(--space-5); }
.story-briefs > li { padding: var(--space-3) 0; border-top: 1px solid var(--line, #ddd); }
.story-pubs { font-size: 0.92em; color: var(--muted, #555); }
.story-card h3, .join-invite h2 { word-break: keep-all; overflow-wrap: anywhere; text-wrap: balance; }
.btn {
  display: inline-block;
  padding: 0.55rem 1rem;
  border: 1px solid var(--accent);
  color: var(--panel);
  background: var(--accent);
  text-decoration: none;
  font-size: 0.95rem;
}
.btn:hover { background: var(--accent-hover); color: var(--panel); }
.btn-secondary {
  background: transparent;
  color: var(--accent);
}
.btn-secondary:hover { background: var(--accent); color: var(--panel); }
.hero figure { margin: 0; }
.hero figcaption, .caption {
  font-size: 0.82rem;
  color: var(--muted);
  margin-top: 0.4rem;
  line-height: 1.5;
}

.section { margin: var(--space-7) 0; }
.section h2, .page-title {
  font-family: var(--font-serif);
  font-size: 1.55rem;
  font-weight: 600;
  margin: 0 0 var(--space-4);
  padding-bottom: 0.4rem;
  border-bottom: 1px solid var(--rule-strong);
}
h3 {
  font-family: var(--font-serif);
  font-size: 1.2rem;
  margin: var(--space-6) 0 var(--space-3);
}

.aims {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: var(--space-4);
}
.aim {
  border-top: 3px solid var(--accent);
  padding: var(--space-4) 0;
}
.aim strong {
  display: block;
  font-family: var(--font-serif);
  font-size: 1.15rem;
  margin-bottom: 0.4rem;
}

.pillars {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: var(--space-5);
}
.pillar figure { margin: 0 0 var(--space-3); }
.pillar-thumbs {
  display: grid;
  gap: 0.35rem;
  margin: 0 0 var(--space-3);
}
.pillar-thumbs.thumbs-2 { grid-template-columns: 1fr 1fr; }
.pillar-thumbs.thumbs-3 { grid-template-columns: repeat(3, minmax(0, 1fr)); }
.pillar-thumbs img {
  display: block;
  width: 100%;
  aspect-ratio: 5 / 4;
  height: auto;
  object-fit: contain;
  background: #fff;
}
.pillar h3 { margin-top: 0; }

.findings { display: grid; gap: var(--space-5); }
.finding {
  display: grid;
  grid-template-columns: minmax(0, 16rem) minmax(0, 1fr);
  gap: var(--space-4);
  padding-bottom: var(--space-5);
  border-bottom: 1px solid var(--rule);
}
.finding figure img {
  width: 100%;
  height: auto;
  background: #fff;
}
.finding h3 { margin-top: 0; }
.finding-subtitle { margin: -0.2rem 0 0.5rem; color: var(--muted); font-size: 0.88rem; }
.opportunity-next { font-family: var(--font-serif); }
.finding-text { grid-template-columns: 1fr; }
.meta { color: var(--muted); font-size: 0.9rem; }

.news-list, .pub-year-list { list-style: none; margin: 0; padding: 0; }
.news-list li {
  display: grid;
  grid-template-columns: 7.5rem 1fr;
  gap: var(--space-4);
  padding: 0.7rem 0;
  border-bottom: 1px solid var(--rule);
}
.news-list time { color: var(--muted); font-variant-numeric: tabular-nums; }
.news-list-title {
  display: flex;
  flex-wrap: wrap;
  align-items: baseline;
  gap: 0.25rem 0.7rem;
}
.lang-badge {
  font-size: 0.75rem;
  color: var(--muted);
  border: 1px solid var(--rule);
  padding: 0.05rem 0.4rem;
  letter-spacing: 0.02em;
}

.people-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(14rem, 1fr));
  gap: var(--space-5);
}
.person-card { text-decoration: none; color: inherit; }
.person-card img { aspect-ratio: 3/4; object-fit: cover; background: #e7e2d8; margin-bottom: 0.6rem; }
.person-card-text { border-top: 3px solid var(--accent); padding-top: 0.85rem; }
.person-monogram {
  display: grid;
  place-items: center;
  width: 2.6rem;
  height: 2.6rem;
  margin-bottom: 0.55rem;
  border: 1px solid var(--rule-strong);
  font-family: var(--font-serif);
  font-size: 1.05rem;
  color: var(--accent);
  background: var(--panel);
}
.person-monogram-lg { width: 3.4rem; height: 3.4rem; font-size: 1.3rem; }
.people-grid-compact { grid-template-columns: repeat(auto-fill, minmax(10rem, 1fr)); gap: var(--space-4); }
.people-grid-compact .person-card img,
.people-grid-compact .person-monogram {
  width: 4.5rem;
  height: 4.5rem;
  aspect-ratio: 1;
  object-fit: cover;
  object-position: center 20%;
  margin: 0 0 0.6rem;
  font-size: 1.4rem;
}
.people-grid-compact .person-card-text { border-top: 0; padding-top: 0; }
.person-card h3 { margin: 0 0 0.2rem; font-size: 1.05rem; border: 0; }
.person-role { color: var(--muted); font-size: 0.88rem; }
.alumni-destination { color: var(--muted); font-size: 0.88rem; margin: 0.15rem 0 0; }

.breadcrumb {
  font-size: 0.88rem;
  color: var(--muted);
  margin-bottom: var(--space-5);
}
.breadcrumb ol { display: flex; flex-wrap: wrap; gap: 0.4rem; list-style: none; margin: 0; padding: 0; }
.breadcrumb li:not(:last-child)::after { content: " /"; margin-left: 0.4rem; color: var(--rule-strong); }

.prose p { margin: 0 0 1.1em; }
.prose ul, .prose ol { margin: 0 0 1.1em; padding-left: 1.3em; }
.figure-block { margin: var(--space-5) 0; }
.figure-block img { width: 100%; background: #fff; }
.figure-row {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: var(--space-3);
  margin: 0 0 var(--space-3);
}
.figure-row img {
  width: 100%;
  height: 10rem;
  object-fit: cover;
  background: #fff;
}
@media (max-width: 640px) {
  .figure-row { grid-template-columns: 1fr; }
  .figure-row img { height: 11rem; }
}
.equipment-item { margin: 0 0 var(--space-5); }
.equipment-item-pending {
  max-width: 36rem;
  padding: 0.9rem 1.05rem;
  border: 1px solid var(--rule);
  background: var(--panel);
}
.equipment-item-pending h2 { margin-top: 0; }
.equipment-item-pending p { margin: 0 0 0.55em; }
.equipment-item-pending p:last-child { margin-bottom: 0; }
.photo-pending { color: var(--muted); font-size: 0.92rem; }

.pub-year { margin: var(--space-6) 0; }
.pub-year h2 { font-size: 1.25rem; }
.pub-item {
  margin: 0 0 1.15rem;
  padding-bottom: 1.15rem;
  border-bottom: 1px solid var(--rule);
  overflow-wrap: anywhere;
}
.pub-item.is-focus-target {
  outline: 2px solid var(--focus);
  outline-offset: 6px;
}
.pub-item .title { font-weight: 600; }
.pub-item .journal { font-style: italic; }
.pub-actions { margin-top: 0.35rem; display: flex; flex-wrap: wrap; gap: 0.75rem; font-size: 0.9rem; }
.copy-cite {
  font: inherit;
  background: none;
  border: 0;
  color: var(--link);
  cursor: pointer;
  padding: 0;
  text-decoration: underline;
  text-underline-offset: 0.18em;
}

.person-hero {
  display: grid;
  grid-template-columns: 10rem 1fr;
  gap: var(--space-5);
  margin-bottom: var(--space-6);
}
.person-hero:not(:has(figure)) {
  grid-template-columns: auto 1fr;
}
details.cv {
  border-top: 1px solid var(--rule);
  padding-top: var(--space-3);
}
details.cv summary { cursor: pointer; font-weight: 600; }
.cv-body { white-space: pre-line; margin-top: var(--space-3); }

.site-footer {
  background: #2a2c2b;
  color: #e7e2d8;
  padding: var(--space-7) 0 var(--space-6);
  font-size: 0.92rem;
}
.site-footer a { color: #d5e6f2; }
.footer-grid {
  display: grid;
  grid-template-columns: 2fr 1fr 1fr;
  gap: var(--space-6);
}
.site-footer h2 { font-size: 1rem; color: #fff; border: 0; margin: 0 0 0.6rem; font-family: var(--font-serif); }
.foot-note { margin-top: var(--space-6); color: #b3aea4; font-size: 0.82rem; }

.more { margin-top: var(--space-4); }

main.is-home {
  padding-top: 0;
}

.hero-stage {
  display: grid;
  grid-template-columns: minmax(0, 0.92fr) minmax(0, 1.08fr);
  gap: var(--space-6);
  align-items: start;
  background: var(--stage);
  color: var(--stage-ink);
  margin: 0 calc(50% - 50vw) var(--space-6);
  padding: var(--space-7) max(1.25rem, calc((100vw - 72rem) / 2 + 1.25rem)) var(--space-6);
}
.hero-stage h1 {
  font-family: var(--font-serif);
  font-size: clamp(1.7rem, 3.2vw, 2.35rem);
  line-height: 1.35;
  font-weight: 600;
  margin: 0 0 var(--space-4);
  color: var(--stage-ink);
  word-break: keep-all;
  overflow-wrap: anywhere;
  text-wrap: balance;
}
.hero-stage .lede { color: var(--stage-muted); }
.hero-stage .brand-tag { color: #e4c4b6; }
.hero-stage .btn-secondary {
  color: var(--stage-ink);
  border-color: var(--stage-ink);
}
.hero-stage .btn-secondary:hover {
  background: var(--stage-ink);
  color: var(--stage);
}
.atlas { display: grid; gap: var(--space-3); }
.atlas-lead,
.atlas-tiles figure,
.visual-strip-item {
  margin: 0;
}
.atlas-lead img,
.atlas-tiles img,
.visual-strip-item img {
  width: 100%;
  height: auto;
  aspect-ratio: 4 / 3;
  object-fit: cover;
  background: #041018;
}
.atlas-lead figcaption,
.atlas-tiles figcaption,
.visual-strip-item span {
  display: block;
  margin-top: 0.35rem;
  font-size: 0.78rem;
  line-height: 1.4;
  color: var(--stage-muted);
}
.atlas-tiles {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: var(--space-3);
}
.visual-strip {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: var(--space-3);
  background: var(--stage-2);
  margin: 0 calc(50% - 50vw) var(--space-7);
  padding: var(--space-4) max(1.25rem, calc((100vw - 72rem) / 2 + 1.25rem));
}
.visual-strip-item {
  color: inherit;
  text-decoration: none;
}
.plain-list { margin: 0 0 var(--space-4); padding-left: 1.2em; }
.commentary-badge a {
  display: inline-block;
  margin-top: 0.4rem;
  padding: 0.15rem 0.55rem;
  border: 1px solid var(--accent);
  color: var(--accent);
  text-decoration: none;
  font-size: 0.88rem;
}
.commentary-badge a:hover { background: var(--accent); color: var(--panel); }
.related-commentary {
  margin: var(--space-5) 0;
  padding: 1rem 1.15rem;
  border-left: 4px solid var(--accent);
  background: var(--stage-2);
  color: var(--stage-ink);
}
.related-commentary a { color: #d5e6f2; }
.related-commentary p { margin: 0 0 0.7em; }
.related-commentary p:last-child { margin-bottom: 0; }
.pub-commentary {
  margin: 0.35rem 0 0;
  font-size: 0.92rem;
  color: var(--ink-soft);
}
.status-note { color: var(--muted); font-size: 0.92rem; }
.work-kicker {
  font-size: 0.78rem;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--accent);
  margin: 0 0 0.35rem;
}
.finding-featured {
  background: var(--panel);
  padding: var(--space-4);
  border: 1px solid var(--rule);
  grid-template-columns: minmax(18rem, 28rem) minmax(0, 1fr);
  align-items: start;
}

@media (max-width: 900px) {
  .hero-stage,
  .visual-strip {
    grid-template-columns: 1fr;
  }
  .atlas-tiles,
  .visual-strip {
    display: flex;
    overflow-x: auto;
    scroll-snap-type: x mandatory;
    -webkit-overflow-scrolling: touch;
  }
  .atlas-tiles figure,
  .visual-strip-item {
    flex: 0 0 78%;
    scroll-snap-align: start;
  }
}

.more { margin-top: var(--space-4); }

.jump-nav {
  margin: var(--space-6) 0;
  padding: var(--space-4);
  background: var(--panel);
  border: 1px solid var(--rule);
}
.jump-nav ul {
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-3) var(--space-5);
  margin: 0;
  padding: 0;
  list-style: none;
}
.opportunity-grid,
.story-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(16rem, 1fr));
  gap: var(--space-5);
  margin: var(--space-5) 0;
}
.opportunity,
.story-card {
  background: var(--panel);
  border: 1px solid var(--rule);
  padding: var(--space-4);
}
.opportunity h3,
.story-card h3 { margin-top: 0; }
.opportunity-links,
.story-links { margin-bottom: 0; }
.opportunity-cta { margin: var(--space-4) 0 var(--space-3); }
.legacy-motto {
  font-style: italic;
  color: var(--muted);
  font-size: 0.9rem;
  margin: 0.35rem 0 0;
}
.funding-wrap { overflow-x: auto; margin: var(--space-5) 0; }
.funding-table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.95rem;
}
.funding-table th,
.funding-table td {
  border: 1px solid var(--rule);
  padding: 0.55rem 0.7rem;
  text-align: left;
  vertical-align: top;
}
.funding-table caption {
  text-align: left;
  font-weight: 600;
  margin-bottom: var(--space-3);
}
.backgrounds { margin: var(--space-4) 0; max-width: 38rem; }
.backgrounds figcaption { font-weight: 600; margin-bottom: var(--space-2); }
.backgrounds-list { list-style: none; margin: 0; padding: 0; }
.backgrounds-list li { display: grid; grid-template-columns: 15rem 1fr 2rem; align-items: center; gap: var(--space-3); padding: 0.2rem 0; }
.bg-bar { height: 0.7rem; background: var(--rule); }
.bg-bar span { display: block; height: 100%; background: var(--accent); }
.bg-count { text-align: right; font-variant-numeric: tabular-nums; }
@media (max-width: 600px) { .backgrounds-list li { grid-template-columns: 9.5rem 1fr 1.5rem; font-size: 0.92rem; } }
.scroll-hint { display: none; font-size: 0.9rem; color: var(--muted); margin: var(--space-4) 0 0; }
@media (max-width: 600px) {
  .funding-table { min-width: 42rem; }
  .scroll-hint { display: block; }
  .funding-wrap { margin-top: var(--space-2); }
}
.inquiry-block { margin-top: var(--space-5); }
.inquiry-template {
  white-space: pre-wrap;
  background: var(--panel);
  border: 1px solid var(--rule);
  padding: var(--space-4);
  font-family: ui-monospace, "SFMono-Regular", Menlo, Consolas, monospace;
  font-size: 0.92rem;
  line-height: 1.6;
  overflow-x: auto;
}
.email-plain {
  user-select: all;
  font-family: ui-monospace, "SFMono-Regular", Menlo, Consolas, monospace;
}
.research-question { margin-top: var(--space-4); }
.photo-pending {
  border: 1px dashed var(--rule-strong);
  padding: var(--space-4);
  color: var(--muted);
}

@media (max-width: 900px) {
  .hero, .aims, .pillars, .finding, .finding-featured, .footer-grid, .person-hero, .news-list li {
    grid-template-columns: 1fr;
  }
  .header-bar {
    display: flex;
    flex-wrap: wrap;
    align-items: flex-start;
    gap: 0.55rem 0.75rem;
  }
  .brand {
    flex: 1 1 100%;
    max-width: 100%;
  }
  .header-tools {
    flex: 1 1 100%;
    margin-left: 0;
    width: 100%;
    justify-content: flex-start;
    flex-wrap: wrap;
    flex-direction: row;
    align-items: center;
    gap: 0.6rem 0.85rem;
  }
  .nav-toggle {
    display: none;
  }
  html.js .nav-toggle {
    display: inline-flex;
    align-items: center;
    white-space: nowrap;
  }
  html.js .site-nav {
    display: none;
    border-top: 1px solid var(--rule);
  }
  html.js .site-nav.is-open { display: block; }
  .site-nav {
    display: block;
    width: 100%;
    flex-basis: 100%;
  }
  .nav-list { flex-direction: column; }
  .nav-list > li > a { padding: 0.45rem 0; }
  .sub-nav {
    position: static;
    border: 0;
    box-shadow: none;
    display: block;
    padding-left: 0.8rem;
    background: transparent;
    min-width: 0;
  }
}

@media (max-width: 600px) {
  body { font-size: 1rem; }
  .wrap { width: min(100% - 1.25rem, var(--page)); }
  .news-list li { gap: 0.2rem; }
  .header-tools {
    flex-direction: row;
    flex-wrap: wrap;
    align-items: center;
    justify-content: flex-start;
    gap: 0.5rem 0.75rem;
  }
}