2021.03.03
Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk
(Transl Psychiatry 11, 151 (2021). https://doi.org/10.1038/s41398-021-01272-3)
Shigemizu D1,2,3, Mitsumori R1, Akiyama S1, Miyashita A4, Morizono T1, Higaki S1, Asanomi Y1, Hara N4, Tamiya G5,6, Kinoshita K5,7, Ikeuchi T4, Niida S1, Ozaki K1,3.
1 Medical Genome Center, National Center for Geriatrics and Gerontology.
2 Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University.
3 RIKEN Center for Integrative Medical Sciences.
4 Department of Molecular Genetics, Brain Research Institute, Niigata University.
5 Tohoku Medical Megabank Organization, Tohoku University.
6 Statistical Genetics Team, RIKEN Center for Advanced Intelligence Project.
7 Graduate School of Information Sciences, Tohoku University.
Abstract
Alzheimer's disease (AD) has no cure, but early detection and risk prediction could allow earlier intervention. Genetic risk factors may differ between ethnic populations. To discover novel susceptibility loci of AD in the Japanese population, we conducted a genome-wide association study (GWAS) with 3962 AD cases and 4074 controls. Out of 4,852,957 genetic markers that passed stringent quality control filters, 134 in nine loci, including APOE and SORL1, were convincingly associated with AD. Lead SNPs located in seven novel loci were genotyped in an independent Japanese AD case-control cohort. The novel locus FAM47E reached genome-wide significance in a meta-analysis of association results. This is the first report associating the FAM47E locus with AD in the Japanese population. A trans-ethnic meta-analysis combining the results of the Japanese data sets with summary statistics from stage 1 data of the International Genomics of Alzheimer's Project identified an additional novel susceptibility locus in OR2B2. Our data highlight the importance of performing GWAS in non-European populations.
