Welcome to Dept. Neuroscience of Disease !
We have been investigating Physiology, Diseases and Disorders of the brain and neurons.


There exist approximately 100,000,000,000 neurons in each human brain, and the number of glia cells is much more than that of neurons. Supposed that each neuron is a star in the Universe, we could compare the brain to a small Universe within. However things are more complicated because each neuron extends long fibers to other neurons for communicating signals. In one sense, the brain, a small Universe, is much more complicated than the Universe itself.

It is theoretically, technically and physically impossible to study all the twinkling stars in the sky. But we could estimate the characters of stars or planets by carefully observing and analyzing the sun and planets in the solar system. It is also impossible to elucidate functions, anatomies and networks of all the neurons one by one, but we are able to reach a right conclusion if we handle a miniature brain and deduce common principles from the mini-brain.

This is the way that we have followed. We will disclose the phenomenon occurring in human brain by studying Fish brain and Fly brain. Especially our aim is to elucidate the mechanism of neurological diseases and disorders, deepening scientific and social understanding for some, or finding a drug for others. We human beings share the same ancestor with Insects in the phylogenetic tree, and have evolved exactly from Fish. It is true that there exist human specific structures, but most of the functions and structures in the human brain are preserved in Fish brain, and central functions and molecules are preserved even in Fly brain. Furthermore we could replicate human neurological diseases in the miniature brain of the Fish and Fly. Our laboratory has tried uncovering the physiological functions and pathophysiology of the brain using Fish and Fly brains, and we will surely find therapies for neurological diseases and disorders.

News & Topics

  • - 2017.10.4,5
    International Meeting on Non-Mammalian Models in Biomedical Research, in Mangarole, India. (Matsui)
  • - 2017.8
    Matsui, H.*, Sugie, A. An optimized method for counting dopaminergic neurons in zebrafish. Plos One (in press)
  • - 2017.8
    Matsui, H.*, Matsui, N. Cerebrospinal fluid injection into adult zebrafish for disease research. J Neural Transm (in press)
  • - 2017.7
    Matsui, H.*, Ryosuke, T. Parkinson’s Disease pathogenesis from the viewpoint of small fish models. J Neural Transm (in press)
  • - 2017.4
    Williams syndrome awareness month !
  • - 2017.4
    Matsui, H. The dopamine system, cerebellum, and nucleus ruber in fish and mammals. Dev Growth Differ (in press)
  • - 2017.4.5
    Mr. Yamazaki (Master course) has joined.
  • - 2017.2
    Matsui, H. The Use of Fish Models to Study Human Neurological Disorders. Neurosci Res (in press)
  • - 2017.1
    Dr. Nitta (PostDoc) has joined.
  • - 2016.09.22
    Sugie, A., Möhl, C., Hakeda-Suzuki, S., Matsui, H., Suzuki, T., Tavosanis, G. Analyzing synaptic modulation of Drosophila photoreceptors after exposure to prolonged light. J Vis Exp (in press)
  • - 2016.07.19
    "Teleost fish models of Parkinson's disease"(Matsui)in 39th Annual Meeting of The Japanese Society of Neuroscience Satellite Symposium "Basal Ganglia in Health and Disease"
  • - 2016.05.18
    "From Fish to Human Neurological Disorders" (Matsui) in 57th Annual Meeting of The Japanese Society of Neurology Symposium "Animal models for studying neurological diseases: from worms to primates"
  • - 2016.04
    2016 Japan Neuroscience Society Young Investigator Award(Matsui)
  • - 2016.03.18~19
    Oral presentation "Molecular dissection of neural degeneration in the Drosophila visual system"(Sugie)in 9th Annual Meeting for Japanese developmental Neuroscientists (Tokyo Medical and Dental University)
  • - 2016.03.16~18
    The third prize in the art competition in in Bonn Brain3 – The general meeting of the Bonn Neuroscience Community. Title「Photoreceptor axon terminals in the Drosophila Visual System」(Sugie)
  • - 2016.03.08
    "Time course and Progression of Parkinson's Disease in Small Fish" (Matsui) in Chiba Univ. Symposium "Chronological change in Brain function"
  • - 2016.02.
    Frontiers in Parkinson's Disease 2016.2. (Vol.9 No.1)【Round Table Discussion パーキンソン病の動物モデル―最近の話題】(Matsui)
  • - 2016.02.16
    Sugie has arrived.
  • - 2016.01.16
    Matsui has arrived.