新潟大学脳研究所 基礎神経科学部門
分子神経生物学分野

2016

  • Namba H, Okubo T, Nawa H.
    Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling.
    Sci Rep. 2016 Mar 3;6:22606. doi: 10.1038/srep22606.

2015

  • Giridharan VV, Thandavarayan RA, Arumugam S, Mizuno M, Nawa H, Suzuki K, Ko KM, Krishnamurthy P, Watanabe K, Konishi T.
    Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression.
    PLoS One. 2015 Nov 10;10(11):e0142483. doi: 10.1371/journal.pone.0142483. eCollection 2015.
  • Nagano T, Mizuno M, Morita K, Nawa H.
    Pathological Implications of Oxidative Stress in Patients and Animal Models with Schizophrenia: The Role of Epidermal Growth Factor Receptor Signaling.
    Curr Top Behav Neurosci. 2015 Oct 17.
  • Sakai M, Watanabe Y, Someya T, Araki K, Shibuya M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Hashimoto T, Hishimoto A, Kitamura N, Iritani S, Shirakawa O, Maeda K, Miyashita A, Niwa S, Takahashi H, Kakita A, Kuwano R, Nawa H.
    Assessment of copy number variations in the brain genome of schizophrenia patients.
    Mol Cytogenet. 2015 Jul 1;8:46. doi: 10.1186/s13039-015-0144-5. eCollection 2015.
  • Kato T, Abe Y, Hirokawa S, Iwakura Y, Mizuno M, Namba H, Nawa H.
    Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801.
    Curr Mol Med. 2015;15(3):222-36.
  • Nakashima M, Saitsu H, Takei N, Tohyama J, Kato M, Kitaura H, Shiina M, Shirouzu H, Masuda H, Watanabe K, Ohba C, Tsurusaki Y, Miyake N, Zheng YJ, Sato T, Takebayashi H, Ogata K, Kameyama S, Kakita A, Matsumoto N
    Somatic Mutations in MTOR Cause Focal cortical dysplasia Type IIb
    Ann. Neurol. 2015 Sep;78(3):375-86. doi: 10.1002/ana.24444.

2014

  • Takei N, Furukawa K, Hanyu O, Sone H, Nawa H.
    A possible link between BDNF and mTOR in control of food intake.
    Front Psychol. 2014 Sep 25;5:1093. doi: 10.3389/fpsyg.2014.01093. eCollection 2014.
  • Nawa H, Sotoyama H, Iwakura Y, Takei N, Namba H.
    Neuropathologic implication of peripheral neuregulin-1 and EGF signals in dopaminergic dysfunction and behavioral deficits relevant to schizophrenia: their target cells and time window.
    Biomed Res Int. 2014;2014:697935. doi: 10.1155/2014/697935.
  • Takei N, Nawa H. mTOR signaling and its roles in normal and abnormal brain development.
    Front Mol Neurosci. 2014 Apr 23;7:28. doi: 10.3389/fnmol.2014.00028.
  • Kunii Y, Miura I, Matsumoto J, Hino M, Wada A, Niwa S, Nawa H, Sakai M, Someya T, Takahashi H, Kakita A, Yabe H.
    Elevated postmortem striatal t-DARPP expression in schizophrenia and associations with DRD2/ANKK1 polymorphism.
    Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 4;53:123-8. doi: 10.1016/j.pnpbp.2014.03.014.
  • Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T, Iwamoto K.
    Increased l1 retrotransposition in the neuronal genome in schizophrenia.
    Neuron. 2014 Jan 22;81(2):306-13. doi: 10.1016/j.neuron.2013.10.053.

2013

  • Ishizuka Y, Kakiya N, Witters LA, Oshiro N, Shirao T, Nawa H, Takei N.
    AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.
    J Neurochem. 2013 Oct;127(1):66-77. doi: 10.1111/jnc.12362.
  • Eda T, Mizuno M, Araki K, Iwakura Y, Namba H, Sotoyama H, Kakita A, Takahashi H, Satoh H, Chan SY, Nawa H.
    Neurobehavioral deficits of epidermal growth factor-overexpressing transgenic mice: impact on dopamine metabolism.
    Neurosci Lett. 2013 Jun 28;547:21-5. doi: 10.1016/j.neulet.2013.04.055.
  • Mizuno M, Sotoyama H, Namba H, Shibuya M, Eda T, Wang R, Okubo T, Nagata K, Iwakura Y, Nawa H.
    ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions.
    Transl Psychiatry. 2013 Apr 30;3:e252. doi: 10.1038/tp.2013.29.
  • Wang R, Iwakura Y, Araki K, Keino-Masu K, Masu M, Wang XY, Takei N, Higashiyama S, Nawa H.
    ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells; re-evaluation of their low-affinity interaction.
    Sci Rep. 2013;3:1402. doi: 10.1038/srep01402.
  • Sotoyama H, Namba H, Chiken S, Nambu A, Nawa H.
    Exposure to the cytokine EGF leads to abnormal hyperactivity of pallidal GABA neurons: implications for schizophrenia and its modeling.
    J Neurochem. 2013 Aug;126(4):518-28. doi: 10.1111/jnc.12223.
  • Iwakura Y, Nawa H.
    ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease.
    Front Cell Neurosci. 2013 Feb 13;7:4. doi: 10.3389/fncel.2013.00004.
  • Tanaka S, Syu A, Ishiguro H, Inada T, Horiuchi Y, Ishikawa M, Koga M, Noguchi E, Ozaki N, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T.
    DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia.
    Pharmacogenomics J. 2013 Feb;13(1):27-34. doi: 10.1038/tpj.2011.

2012

  • Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, Nawa H, Saido TC.
    Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
    J Biol Chem. 2012 Aug 24;287(35):29362-72. doi: 10.1074/jbc.M112.340372.
  • Nawa H, Yamada K.
    Experimental schizophrenia models in rodents established with inflammatory agents and cytokines.
    Methods Mol Biol. 2012;829:445-51. doi: 10.1007/978-1-61779-458-2_28.
  • Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T.
    Association of SNPs linked to increased expression of SLC1A1 with schizophrenia.
    Am J Med Genet B Neuropsychiatr Genet. 2012 Jan;159B(1):30-7. doi: 10.1002/ajmg.b.31249.

2011

  • Sotoyama H, Zheng Y, Iwakura Y, Mizuno M, Aizawa M, Shcherbakova K, Wang R, Namba H, Nawa H.
    Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF.
    PLoS One. 2011;6(10):e25831. doi: 10.1371/journal.pone.0025831. Epub 2011 Oct 12.
  • Fuyamada M, Nawa H, Shibata M, Yoshida K, Kise Y, Katsumata A, Ariji E, Goto S.
    Reproducibility of landmark identification in the jaw and teeth on 3-dimensional cone-beam computed tomography images.
    Angle Orthod. 2011 Sep;81(5):843-9. doi: 10.2319/010711-5.1.
  • Wang R, Iwakura Y, Araki K, Sotoyama H, Takei N, Nawa H.
    In vitro production of an active neurotrophic factor, neuregulin-1: qualitative comparison of different cell-free translation systems.
    Neurosci Lett. 2011 Jun 22;497(2):90-3. doi: 10.1016/j.neulet.2011.04.036.
  • Iwakura Y, Wang R, Abe Y, Piao YS, Shishido Y, Higashiyama S, Takei N, Nawa H.
    Dopamine-dependent ectodomain shedding and release of epidermal growth factor in developing striatum: target-derived neurotrophic signaling (Part 2).
    J Neurochem. 2011 Jul;118(1):57-68. doi: 10.1111/j.1471-4159.2011.07295.x.
  • Iwakura Y, Zheng Y, Sibilia M, Abe Y, Piao YS, Yokomaku D, Wang R, Ishizuka Y, Takei N, Nawa H.
    Qualitative and quantitative re-evaluation of epidermal growth factor-ErbB1 action on developing midbrain dopaminergic neurons in vivo and in vitro: target-derived neurotrophic signaling (Part 1).
    J Neurochem. 2011 Jul;118(1):45-56. doi: 10.1111/j.1471-4159.2011.07287.x.
  • Abe Y, Namba H, Kato T, Iwakura Y, Nawa H.
    Neuregulin-1 signals from the periphery regulate AMPA receptor sensitivity and expression in GABAergic interneurons in developing neocortex.
    J Neurosci. 2011 Apr 13;31(15):5699-709. doi: 10.1523/JNEUROSCI.3477-10.2011.
  • Aizawa M, Abe Y, Ito T, Handa H, Nawa H.
    mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain.
    Neurosci Res. 2011 Apr;69(4):343-7. doi: 10.1016/j.neures.2010.12.019.

2010

  • Kato T, Kasai A, Mizuno M, Fengyi L, Shintani N, Maeda S, Yokoyama M, Ozaki M, Nawa H.
    Phenotypic characterization of transgenic mice overexpressing neuregulin-1.
    PLoS One. 2010 Dec 9;5(12):e14185. doi: 10.1371/journal.pone.0014185.
  • Mizuno M, Iwakura Y, Shibuya M, Zheng Y, Eda T, Kato T, Takasu Y, Nawa H.
    Antipsychotic potential of quinazoline ErbB1 inhibitors in a schizophrenia model established with neonatal hippocampal lesioning.
    J Pharmacol Sci. 2010;114(3):320-31. Epub 2010 Oct 14.
  • Mizuno M, Kawamura H, Ishizuka Y, Sotoyama H, Nawa H.
    The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats.
    Pharmacol Biochem Behav. 2010 Dec;97(2):392-8. doi: 10.1016/j.pbb.2010.09.009.
  • Watanabe Y, Someya T, Nawa H.
    Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models.
    Psychiatry Clin Neurosci. 2010 Jun;64(3):217-30. doi: 10.1111/j.1440-1819.2010.02094.x.
  • Qi S, Mizuno M, Yonezawa K, Nawa H, Takei N.
    Activation of mammalian target of rapamycin signaling in spatial learning.
    Neurosci Res. 2010 Oct;68(2):88-93. doi: 10.1016/j.neures.2010.06.008.
  • Shibuya M, Komi E, Wang R, Kato T, Watanabe Y, Sakai M, Ozaki M, Someya T, Nawa H.
    Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism.
    J Neural Transm (Vienna). 2010 Jul;117(7):887-95. doi: 10.1007/s00702-010-0418-3.
  • Kato T, Abe Y, Sotoyama H, Kakita A, Kominami R, Hirokawa S, Ozaki M, Takahashi H, Nawa H.
    Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia.
    Mol Psychiatry. 2011 Mar;16(3):307-20. doi: 10.1038/mp.2010.10. Epub 2010 Feb 9. Erratum in: Mol Psychiatry. 2013 Aug;18(8):951.