Research Findings

2019/02/13

Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri

Cell Rep. 2019 Feb 12;26(7):1727-1733.e6. doi: 10.1016/j.celrep.2019.01.015.

Matsui H1, Kenmochi N2, Namikawa K3.

1Department of Neuroscience of Disease, Center for Transdisciplinary Research; Brain Research Institute, Niigata University; Department of Neuroscience, University of Miyazaki, Faculty of Medicine
2Frontier Science Research Center, University of Miyazaki
3Cellular and Molecular Neurobiology, Zoological Institute, Technical University Braunschweig, Germany

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized by α-synuclein-positive inclusion bodies and loss of neurons, including dopaminergic neurons. Difficulty in replicating PD phenotypes using animal models partly limits the understanding of PD and the therapy required. Although PD is strongly associated with aging, most experimental animals may not exhibit age-related symptoms. Herein, we demonstrate that Nothobranchius furzeri, a rapidly aging teleost with a short life span, exhibits age-dependent degeneration of dopaminergic and noradrenergic neurons and progression of α-synuclein pathologies. These pathological phenotypes are similar to those observed in human patients with PD. Amelioration of the cell loss by genetic depletion of α-synuclein suggests that α-synuclein is not a bystander but a causative protein of neurodegeneration. N. furzeri can reveal mechanisms underlying PD, especially of the idiopathic form that affects a majority of patients with PD, including α-synuclein-dependent neurodegeneration, age-dependent phenotypes, and progression of α-synuclein pathology.

*Reprinted under a CC BY NC ND 4.0 license.

Related BRI Department

Related Sites

  • Niigata University Graduate School of Medical and Dental Sciences
  • School of Medicine, Faculty of Medicine, Niigata University
  • Niigata University
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